The Ca2+ channel CatSper is not activated by cAMP/PKA signaling but directly affected by chemicals used to probe the action of cAMP and PKA
T Wang, S Young, H Krenz, F Tüttelmann, A Röpke, C Krallmann, S Kliesch, XH Zeng, C Brenker, T Strünker., 18.09.2020
WANG, Tao, et al. The Ca2+ channel CatSper is not activated by cAMP/PKA signaling but directly affected by chemicals used to probe the action of cAMP and PKA. Journal of Biological Chemistry, 2020, 295. Jg., Nr. 38, S. 13181-13193.
Publication: https://doi.org/10.1074/jbc.RA120.013218
Disclaimer
The publication The Ca2+ channel CatSper is not activated by cAMP/PKA signaling but directly affected by chemicals used to probe the action of cAMP and PKA by T Wang, S Young, H Krenz, F Tüttelmann, A Röpke, C Krallmann, S Kliesch, XH Zeng, C Brenker, T Strünker. is not published under an open access license.
Therefore, only content curated by the MFGA team can be shown.
For abstract, images and tables please follow the link to the original publication.
Curation by the MFGA team
Relevant data sets presented in the publication have been identified. If possible, annotations (title, general information,
conditions, processed tissue types and processed cell types) have been added based on information from the publication.
Data set 1: CatSper is not activated by intracellular cAMP or cAMP/PKA signaling
Proteome: Functional Study
Conditions
Human phenotype ontology |
Participants |
Comment |
HP:control |
|
|
Cell Types
Cell ontology |
Maturity |
Description |
Species |
Replicates |
Cells per replicate |
CL_0000019: sperm |
|
sample sizes (50 versus 16) |
|
|
|
Data set 2: Membrane-permeable cAMP analogs activate CatSper only from the outside
Proteome: Functional Study
Conditions
Human phenotype ontology |
Participants |
Comment |
HP:control |
3 |
|
HP:other: Other |
3 |
Sperm lacking functional CatSper channels (CATSPER2−/−). |
Cell Types
Cell ontology |
Maturity |
Description |
Species |
Replicates |
Cells per replicate |
CL_0000019: sperm |
|
|
|
|
|
Data set 3: Human CatSper is activated by cyclic nucleotides via a so-far-unknown binding site
Proteome: Functional Study
Data set 4: The action of PKA inhibitors on CatSper does not rest on inhibition of PKA
Proteome: Functional Study
Conditions
Human phenotype ontology |
Participants |
Comment |
HP:control |
|
|
Cell Types
Cell ontology |
Maturity |
Description |
Species |
Replicates |
Cells per replicate |
CL_0000019: sperm |
|
|
|
|
|