Testicular Architecture of Men with 46,XX Testicular Disorders of Sex Development
Hiort M, Rohayem J, Knaf R, Laurentino S, Berglund A, Gravholt CH, Gromoll J, Wistuba J, 06.02.2023
Hiort M, Rohayem J, Knaf R, Laurentino S, Berglund A, Gravholt CH, Gromoll J, Wistuba J. Testicular Architecture of Men with 46,XX Testicular Disorders of Sex Development. Sex Dev. 2023;17(1):32-42. doi: 10.1159/000528955. Epub 2023 Feb 6. PMID: 36746123.
Publication: https://doi.org/10.1159/000528955
Disclaimer
The publication Testicular Architecture of Men with 46,XX Testicular Disorders of Sex Development by Hiort M, Rohayem J, Knaf R, Laurentino S, Berglund A, Gravholt CH, Gromoll J, Wistuba J is not published under an open access license. Therefore, only content curated by the MFGA team can be shown. For abstract, images and tables please follow the link to the original publication.
Curation by the MFGA team Relevant data sets presented in the publication have been identified. If possible, annotations (title, general information, conditions, processed tissue types and processed cell types) have been added based on information from the publication.
Data set 1: Testicular tissue composition of patients with 46,XX TDSD, NS, KS and AZF deletions
Other: Immunohistochemical staining
Species
| Species |
|---|
| Human |
Tissue Types
| BRENDA tissue ontology | Maturity | Description | Species | Replicates |
|---|---|---|---|---|
| BTO_0001363: testis | adult men with 46,XX testicular DSD | A typically paired male reproductive gland that produces sperm and that in most mammals is contained within the scrotum at sexual maturity. | Human | 4 |
| BTO_0001363: testis | adult men with azoospermia factor deletions | A typically paired male reproductive gland that produces sperm and that in most mammals is contained within the scrotum at sexual maturity. | Human | 5 |
| BTO_0001363: testis | adult men with normal spermatogenesis | A typically paired male reproductive gland that produces sperm and that in most mammals is contained within the scrotum at sexual maturity. | Human | 4 |
| BTO_0001363: testis | adult men with Klinefelter syndrome | A typically paired male reproductive gland that produces sperm and that in most mammals is contained within the scrotum at sexual maturity. | Human | 4 |
Cell Types
| Cell ontology | Maturity | Description | Species | Replicates | Cells per replicate |
|---|---|---|---|---|---|
| CL_0000586: male germ cell | A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis. | Human | |||
| CL_0000216: Sertoli cell | A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier. | Human | |||
| CL_0000178: Leydig cell | A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis. | Human |