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DNA Demethylation Dynamics in the Human Prenatal Germline

Sofia Gkountela, Kelvin X. Zhang, Tiasha A. Shafiq, Wen-Wie Liao, Joseph Hargan-Calvopiña, Pao-Yang Chen, Amander T. Clark, 04.06.2015

GKOUNTELA, Sofia, et al. DNA demethylation dynamics in the human prenatal germline. Cell, 2015, 161. Jg., Nr. 6, S. 1425-1436.

Publication: https://doi.org/10.1016/j.cell.2015.05.012
Repository: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE63392;https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE63393

Disclaimer

The publication DNA Demethylation Dynamics in the Human Prenatal Germline by Sofia Gkountela, Kelvin X. Zhang, Tiasha A. Shafiq, Wen-Wie Liao, Joseph Hargan-Calvopiña, Pao-Yang Chen, Amander T. Clark is not published under an open access license. Therefore, only content curated by the MFGA team can be shown. For abstract, images and tables please follow the link to the original publication.

Curation by the MFGA team
Relevant data sets presented in the publication have been identified. If possible, annotations (title, general information, conditions, processed tissue types and processed cell types) have been added based on information from the publication.

Data set 1: Transcriptional landmarks of human prenatal germline development

Transcriptome: Bulk RNA-Sequencing

Species

Species
Human

Tissue Types

BRENDA tissue ontology Maturity Description Species Replicates
BTO_0000975: ovary Prenatal Human 9
BTO_0001363: testis Prenatal Human 6

Cell Types

Cell ontology Maturity Description Species Replicates Cells per replicate
CL_0000670: primordial germ cell Primordial Human 7
Human advanced germline cells (hAGCs) Human 8
CL_0002322: embryonic stem cell Embryonic Human 4

Data set 2: DNA methylation in the human germline using developmental landmarks as guides

Methylome: Whole Genome Bisulfite Sequencing

Species

Species
Human

Tissue Types

BRENDA tissue ontology Maturity Description Species Replicates
BTO_0000975: ovary Prenatal Human 4
BTO_0001363: testis Prenatal Human 2

Cell Types

Cell ontology Maturity Description Species Replicates Cells per replicate
CL_0000670: primordial germ cell Primordial Human primordial germ cells (hPGCs) Human 3
Advanced germline cells (hAGCs) Human 3
CL_0002322: embryonic stem cell Embryonic Human 5
Embryonic Human inner cell mass (hICM) Human 1