Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells
Kotaro Sasaki, Shihori Yokobayashi, Tomonori Nakamura, ..., Kazutoshi Takahashi, Shinya Yamanaka, Mitinori Saitou, 06.08.2015
SASAKI, Kotaro, et al. Robust in vitro induction of human germ cell fate from pluripotent stem cells. Cell stem cell, 2015, 17. Jg., Nr. 2, S. 178-194.
Publication: http://dx.doi.org/10.1016/j.stem.2015.06.014
Repository: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE67259
Disclaimer
The publication Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells by Kotaro Sasaki, Shihori Yokobayashi, Tomonori Nakamura, ..., Kazutoshi Takahashi, Shinya Yamanaka, Mitinori Saitou is not published under an open access license.
Therefore, only content curated by the MFGA team can be shown.
For abstract, images and tables please follow the link to the original publication.
Curation by the MFGA team
Relevant data sets presented in the publication have been identified. If possible, annotations (title, general information,
conditions, processed tissue types and processed cell types) have been added based on information from the publication.
Data set 1: Differentially expressed genes, compared between key cell types during human PGCLC induction
Transcriptome: Bulk RNA-Sequencing
Tissue Types
| BRENDA tissue ontology |
Maturity |
Description |
Species |
Replicates |
| BTO_0000089: blood |
|
|
Human |
|
Cell Types
| Cell ontology |
Maturity |
Description |
Species |
Replicates |
Cells per replicate |
| CL_0002248: pluripotent stem cell |
|
Male induced pluripotent stem celllines (hiPSCs) |
Human |
|
|
|
|
Incipient mesoderm-like cells (iMeLC) |
Human |
|
|
|
Primordial |
hPGCLC |
Human |
|
|
| CL_2000001: peripheral blood mononuclear cell |
|
Peripheral mononuclear blood cells (PMBCs) |
Human |
|
|
Data set 2: Differentially expressed genes, compared between key cell types during murine PGCLC induction
Transcriptome: Bulk RNA-Sequencing
Cell Types
| Cell ontology |
Maturity |
Description |
Species |
Replicates |
Cells per replicate |
| CL_0002322: embryonic stem cell |
|
Murine embryonic stem cells (mESCs) |
Mouse |
|
|
|
|
Induced pre-gastrulation epiblast-like cells (EpiLCs) |
Mouse |
|
|
|
Primordial |
Primordial germ cell-like cells (mPGCLCs) |
Mouse |
|
|
| CL_0000352: epiblast cell |
|
Epiblast stem cells (EpiSCs) |
Mouse |
|
|
|
|
Incipient mesoderm/primitive streak-like cells (iMeLCs) |
Human |
|
|
| CL_0002248: pluripotent stem cell |
|
Human induced pluripotent stem cells (hiPSCs) |
Human |
|
|
Data set 3: Epigenetic properties of hPGCLCs affecting imprinting regions
Methylome: Other
Cell Types
| Cell ontology |
Maturity |
Description |
Species |
Replicates |
Cells per replicate |
| CL_0002248: pluripotent stem cell |
|
Human induced pluripotent stem celllines (hiPSCs) |
Human |
|
|
|
|
Day eight human primordial germ cell-like cells (d8hPGCLCs) |
Human |
|
|
Data set 4: A Critical Function of BLIMP1 in hPGCLC Specification
Transcriptome: Bulk RNA-Sequencing
Cell Types
| Cell ontology |
Maturity |
Description |
Species |
Replicates |
Cells per replicate |
|
Primordial |
wild-type; BLIMP1+/+; human primordial germ cell-like cells (hPGCLCs) |
Human |
|
|
| CL_0002248: pluripotent stem cell |
Primordial |
BTAG; BLIMP1−/−; Human induced PSCs |
Human |
|
|
