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The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells

Fan Guo, Liying Yan, Hongshan Guo, Lin Li, Boqiang Hu, Yangyu Zhao, Jun Yong, Yuqiong Hu, Xiaoye Wang, Yuan Wie, Wie Wang, Rong Li, Jie Yan, Xu Zhi, Yan Zhang, Hongyan Jin, Wenxin Zhang, YuHou…Jie Qiao, 04.06.2015

GUO, Fan, et al. The transcriptome and DNA methylome landscapes of human primordial germ cells. Cell, 2015, 161. Jg., Nr. 6, S. 1437-1452.

Publication: https://doi.org/10.1016/j.cell.2015.05.015
Repository: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE63818

Disclaimer

The publication The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells by Fan Guo, Liying Yan, Hongshan Guo, Lin Li, Boqiang Hu, Yangyu Zhao, Jun Yong, Yuqiong Hu, Xiaoye Wang, Yuan Wie, Wie Wang, Rong Li, Jie Yan, Xu Zhi, Yan Zhang, Hongyan Jin, Wenxin Zhang, YuHou…Jie Qiao is not published under an open access license. Therefore, only content curated by the MFGA team can be shown. For abstract, images and tables please follow the link to the original publication.

Curation by the MFGA team
Relevant data sets presented in the publication have been identified. If possible, annotations (title, general information, conditions, processed tissue types and processed cell types) have been added based on information from the publication.

Data set 1: Transcriptional Profiles of Human PGCs

Transcriptome: Single-cell RNA-Sequencing

Species

Species
Human

Tissue Types

BRENDA tissue ontology Maturity Description Species Replicates
BTO_0000534: gonad Embryonic Human

Cell Types

Cell ontology Maturity Description Species Replicates Cells per replicate
CL_0000670: primordial germ cell Primordial Human 15 233
CL_0002371: somatic cell Embryonic Gonadal Human 13 86

Data set 2: Dynamic Methylome Analysis of Human PGCs Revealed a Global DNA Hypomethylation Pattern

Methylome: Whole Genome Bisulfite Sequencing

Species

Species
Human

Tissue Types

BRENDA tissue ontology Maturity Description Species Replicates
BTO_0000142: brain Embryonic 5 week post-implantation embryo Human 1.0
BTO_0000562: heart Embryonic 5 week post-implantation embryo Human 1.0
BTO_0000759: liver Embryonic 5 week post-implantation embryo Human 1.0
BTO_0000379: embryo Human

Cell Types

Cell ontology Maturity Description Species Replicates Cells per replicate
CL_0000670: primordial germ cell Primordial Human 10.0
CL_0002371: somatic cell Embryonic Gonadal Human 11.0
CL_0000352: epiblast cell Embryonic E6.5 post-implantation Mouse 1.0 2.0
Embryonic Inner cell mass (ICM) Human 1.0 1.0
CL_0000670: primordial germ cell Primordial Mouse 1.0 8.0
CL_0002322: embryonic stem cell Embryonic Human embryonic stem cells Human 1.0 6.0