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Table S4: KEGG Up in Human SSC

HERMANN, Brian P., et al. The mammalian spermatogenesis single-cell transcriptome, from spermatogonial stem cells to spermatids. Cell reports, 2018, 25. Jg., Nr. 6, S. 1650-1667. e8.

Publication: https://doi.org/10.1016/j.celrep.2018.10.026

Description

KEGG = database for GO term analysis

Disclaimer

The publication The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to Spermatids by Brian P. Hermann, Keren Cheng, Anukriti Singh, Lorena Roa-De La Cruz, Kazadi N. Mutoji, I-Chung Chen, Heidi Gildersleeve, Jake D. Lehle, Max Mayo, Birgit Westernströer, Nathan C. Law, Melissa J. Oatley, Ellen K. Velte, Bryan A. Niedenberger, Danielle Fritze, Sherman Silber, Christopher B. Geyer, Jon M. Oatley, John R. McCarrey is published under an open access no derivatives license: : https://creativecommons.org/licenses/by-nc-nd/4.0/. Granted rights: share — copy and redistribute the material in any medium or format. No alterations allowed. Thus, tables can not be shown in MFGA format.

Curation by the MFGA team

Pie chart of selected column

Table

GENE PVALUE Term Adjusted.p.value Old.p.value Old.adjusted.p.value Z.score Combined.score
EIF4A2 0.000009 RNA transport_Homo sapiens_hsa03013 0.001308987816446 8.10770779227424e-05 0.011350790909184 -1.8671551948893 21.6219251351046
PABPC4 0.000009 RNA transport_Homo sapiens_hsa03013 0.001308987816446 8.10770779227424e-05 0.011350790909184 -1.8671551948893 21.6219251351046
EIF3J 0.000009 RNA transport_Homo sapiens_hsa03013 0.001308987816446 8.10770779227424e-05 0.011350790909184 -1.8671551948893 21.6219251351046
EIF4A3 0.000009 RNA transport_Homo sapiens_hsa03013 0.001308987816446 8.10770779227424e-05 0.011350790909184 -1.8671551948893 21.6219251351046
SAP18 0.000009 RNA transport_Homo sapiens_hsa03013 0.001308987816446 8.10770779227424e-05 0.011350790909184 -1.8671551948893 21.6219251351046
UPF3A 0.000009 RNA transport_Homo sapiens_hsa03013 0.001308987816446 8.10770779227424e-05 0.011350790909184 -1.8671551948893 21.6219251351046
PABPC1 0.000009 RNA transport_Homo sapiens_hsa03013 0.001308987816446 8.10770779227424e-05 0.011350790909184 -1.8671551948893 21.6219251351046
RAN 0.000009 RNA transport_Homo sapiens_hsa03013 0.001308987816446 8.10770779227424e-05 0.011350790909184 -1.8671551948893 21.6219251351046
KPNB1 0.000009 RNA transport_Homo sapiens_hsa03013 0.001308987816446 8.10770779227424e-05 0.011350790909184 -1.8671551948893 21.6219251351046
RNMT 0.000085 mRNA surveillance pathway_Homo sapiens_hsa03015 0.005928946596846 0.000426079554962 0.029825568847321 -1.69909496397907 15.9314007545426
PABPC4 0.000085 mRNA surveillance pathway_Homo sapiens_hsa03015 0.005928946596846 0.000426079554962 0.029825568847321 -1.69909496397907 15.9314007545426
EIF4A3 0.000085 mRNA surveillance pathway_Homo sapiens_hsa03015 0.005928946596846 0.000426079554962 0.029825568847321 -1.69909496397907 15.9314007545426
SAP18 0.000085 mRNA surveillance pathway_Homo sapiens_hsa03015 0.005928946596846 0.000426079554962 0.029825568847321 -1.69909496397907 15.9314007545426
UPF3A 0.000085 mRNA surveillance pathway_Homo sapiens_hsa03015 0.005928946596846 0.000426079554962 0.029825568847321 -1.69909496397907 15.9314007545426
PABPC1 0.000085 mRNA surveillance pathway_Homo sapiens_hsa03015 0.005928946596846 0.000426079554962 0.029825568847321 -1.69909496397907 15.9314007545426
BTG3 0.000361 RNA degradation_Homo sapiens_hsa03018 0.015195192417689 0.001403250372365 0.051566070791117 -1.80701249140873 14.3241452800025
BTG1 0.000361 RNA degradation_Homo sapiens_hsa03018 0.015195192417689 0.001403250372365 0.051566070791117 -1.80701249140873 14.3241452800025
PABPC4 0.000361 RNA degradation_Homo sapiens_hsa03018 0.015195192417689 0.001403250372365 0.051566070791117 -1.80701249140873 14.3241452800025
PABPC1 0.000361 RNA degradation_Homo sapiens_hsa03018 0.015195192417689 0.001403250372365 0.051566070791117 -1.80701249140873 14.3241452800025
ENO1 0.000361 RNA degradation_Homo sapiens_hsa03018 0.015195192417689 0.001403250372365 0.051566070791117 -1.80701249140873 14.3241452800025
LDHB 0.000434 Cysteine and methionine metabolism_Homo sapiens_hsa00270 0.015195192417689 0.001473316308318 0.051566070791117 -1.75325713865371 13.5739346113378
AMD1 0.000434 Cysteine and methionine metabolism_Homo sapiens_hsa00270 0.015195192417689 0.001473316308318 0.051566070791117 -1.75325713865371 13.5739346113378
SMS 0.000434 Cysteine and methionine metabolism_Homo sapiens_hsa00270 0.015195192417689 0.001473316308318 0.051566070791117 -1.75325713865371 13.5739346113378
SRM 0.000434 Cysteine and methionine metabolism_Homo sapiens_hsa00270 0.015195192417689 0.001473316308318 0.051566070791117 -1.75325713865371 13.5739346113378
DYNC1LI1 0.005054 Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 0.117918354262324 0.011866013909327 0.276873657884297 -1.74255841546131 9.21403161778279
DYNLL1 0.005054 Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 0.117918354262324 0.011866013909327 0.276873657884297 -1.74255841546131 9.21403161778279
VAMP2 0.005054 Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 0.117918354262324 0.011866013909327 0.276873657884297 -1.74255841546131 9.21403161778279
AMD1 0.007226 Arginine and proline metabolism_Homo sapiens_hsa00330 0.140957084781336 0.01641822053785 0.317179220365639 -1.62496663834161 8.01123166673391
SMS 0.007226 Arginine and proline metabolism_Homo sapiens_hsa00330 0.140957084781336 0.01641822053785 0.317179220365639 -1.62496663834161 8.01123166673391
SRM 0.007226 Arginine and proline metabolism_Homo sapiens_hsa00330 0.140957084781336 0.01641822053785 0.317179220365639 -1.62496663834161 8.01123166673391
GSTP1 0.008055 Glutathione metabolism_Homo sapiens_hsa00480 0.140957084781336 0.018124526878037 0.317179220365639 -1.56915589725178 7.56568622423565
SMS 0.008055 Glutathione metabolism_Homo sapiens_hsa00480 0.140957084781336 0.018124526878037 0.317179220365639 -1.56915589725178 7.56568622423565
SRM 0.008055 Glutathione metabolism_Homo sapiens_hsa00480 0.140957084781336 0.018124526878037 0.317179220365639 -1.56915589725178 7.56568622423565
ITGB1 0.009399 Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 0.146206153176374 0.020862777344271 0.324532092021992 -1.52923307679183 7.13716855050456
TUBA1B 0.009399 Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 0.146206153176374 0.020862777344271 0.324532092021992 -1.52923307679183 7.13716855050456
KRT18 0.009399 Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 0.146206153176374 0.020862777344271 0.324532092021992 -1.52923307679183 7.13716855050456
TKTL1 0.018687 Metabolic pathways_Homo sapiens_hsa01100 0.21801954768831 0.125288033386346 0.730846861420355 -1.7384261976974 6.91877341930842
PDXK 0.018687 Metabolic pathways_Homo sapiens_hsa01100 0.21801954768831 0.125288033386346 0.730846861420355 -1.7384261976974 6.91877341930842
UXS1 0.018687 Metabolic pathways_Homo sapiens_hsa01100 0.21801954768831 0.125288033386346 0.730846861420355 -1.7384261976974 6.91877341930842
UROS 0.018687 Metabolic pathways_Homo sapiens_hsa01100 0.21801954768831 0.125288033386346 0.730846861420355 -1.7384261976974 6.91877341930842
PTGES3 0.018687 Metabolic pathways_Homo sapiens_hsa01100 0.21801954768831 0.125288033386346 0.730846861420355 -1.7384261976974 6.91877341930842
AMD1 0.018687 Metabolic pathways_Homo sapiens_hsa01100 0.21801954768831 0.125288033386346 0.730846861420355 -1.7384261976974 6.91877341930842
NME3 0.018687 Metabolic pathways_Homo sapiens_hsa01100 0.21801954768831 0.125288033386346 0.730846861420355 -1.7384261976974 6.91877341930842
UAP1 0.018687 Metabolic pathways_Homo sapiens_hsa01100 0.21801954768831 0.125288033386346 0.730846861420355 -1.7384261976974 6.91877341930842
ENO1 0.018687 Metabolic pathways_Homo sapiens_hsa01100 0.21801954768831 0.125288033386346 0.730846861420355 -1.7384261976974 6.91877341930842
AK5 0.018687 Metabolic pathways_Homo sapiens_hsa01100 0.21801954768831 0.125288033386346 0.730846861420355 -1.7384261976974 6.91877341930842
PTS 0.018687 Metabolic pathways_Homo sapiens_hsa01100 0.21801954768831 0.125288033386346 0.730846861420355 -1.7384261976974 6.91877341930842
SRM 0.018687 Metabolic pathways_Homo sapiens_hsa01100 0.21801954768831 0.125288033386346 0.730846861420355 -1.7384261976974 6.91877341930842
GALNS 0.018687 Metabolic pathways_Homo sapiens_hsa01100 0.21801954768831 0.125288033386346 0.730846861420355 -1.7384261976974 6.91877341930842
LDHB 0.018687 Metabolic pathways_Homo sapiens_hsa01100 0.21801954768831 0.125288033386346 0.730846861420355 -1.7384261976974 6.91877341930842
SMS 0.018687 Metabolic pathways_Homo sapiens_hsa01100 0.21801954768831 0.125288033386346 0.730846861420355 -1.7384261976974 6.91877341930842
ALDOA 0.018687 Metabolic pathways_Homo sapiens_hsa01100 0.21801954768831 0.125288033386346 0.730846861420355 -1.7384261976974 6.91877341930842
POLR2L 0.018687 Metabolic pathways_Homo sapiens_hsa01100 0.21801954768831 0.125288033386346 0.730846861420355 -1.7384261976974 6.91877341930842
LDHB 0.016026 Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 0.203972819553223 0.033966540166529 0.432301420301276 -1.64917355747578 6.81688476102786
ENO1 0.016026 Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 0.203972819553223 0.033966540166529 0.432301420301276 -1.64917355747578 6.81688476102786
ALDOA 0.016026 Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 0.203972819553223 0.033966540166529 0.432301420301276 -1.64917355747578 6.81688476102786
TKTL1 0.020840 Biosynthesis of amino acids_Homo sapiens_hsa01230 0.218977995149795 0.043182307713198 0.439470145030622 -1.38515542662569 5.36174225354118
ENO1 0.020840 Biosynthesis of amino acids_Homo sapiens_hsa01230 0.218977995149795 0.043182307713198 0.439470145030622 -1.38515542662569 5.36174225354118
ALDOA 0.020840 Biosynthesis of amino acids_Homo sapiens_hsa01230 0.218977995149795 0.043182307713198 0.439470145030622 -1.38515542662569 5.36174225354118
XRCC6 0.004569 Non-homologous end-joining_Homo sapiens_hsa03450 0.117918354262324 0.009825548114237 0.275115347198648 -0.971061260031606 5.23261469264929
XRCC5 0.004569 Non-homologous end-joining_Homo sapiens_hsa03450 0.117918354262324 0.009825548114237 0.275115347198648 -0.971061260031606 5.23261469264929
ID1 0.028946 TGF-beta signaling pathway_Homo sapiens_hsa04350 0.242884933959828 0.058286191638938 0.510004176840703 -1.41999162369716 5.03008781255132
ID4 0.028946 TGF-beta signaling pathway_Homo sapiens_hsa04350 0.242884933959828 0.058286191638938 0.510004176840703 -1.41999162369716 5.03008781255132
SKP1 0.028946 TGF-beta signaling pathway_Homo sapiens_hsa04350 0.242884933959828 0.058286191638938 0.510004176840703 -1.41999162369716 5.03008781255132
CST3 0.033538 Salivary secretion_Homo sapiens_hsa04970 0.250458083022754 0.066657813092618 0.537137626908502 -1.34823065610428 4.57734573874934
ATP1B3 0.033538 Salivary secretion_Homo sapiens_hsa04970 0.250458083022754 0.066657813092618 0.537137626908502 -1.34823065610428 4.57734573874934
VAMP2 0.033538 Salivary secretion_Homo sapiens_hsa04970 0.250458083022754 0.066657813092618 0.537137626908502 -1.34823065610428 4.57734573874934
ITGB1 0.033991 Phagosome_Homo sapiens_hsa04145 0.250458083022754 0.076504842850037 0.563719894684483 -1.27448409950463 4.30988101140163
DYNC1LI1 0.033991 Phagosome_Homo sapiens_hsa04145 0.250458083022754 0.076504842850037 0.563719894684483 -1.27448409950463 4.30988101140163
TUBA1B 0.033991 Phagosome_Homo sapiens_hsa04145 0.250458083022754 0.076504842850037 0.563719894684483 -1.27448409950463 4.30988101140163
RAC1 0.033991 Phagosome_Homo sapiens_hsa04145 0.250458083022754 0.076504842850037 0.563719894684483 -1.27448409950463 4.30988101140163
HSPH1 0.045255 Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 0.309862321356538 0.098763167299723 0.642047005471886 -1.36071500477977 4.21201603890795
UBE2E2 0.045255 Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 0.309862321356538 0.098763167299723 0.642047005471886 -1.36071500477977 4.21201603890795
RAD23A 0.045255 Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 0.309862321356538 0.098763167299723 0.642047005471886 -1.36071500477977 4.21201603890795
SKP1 0.045255 Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 0.309862321356538 0.098763167299723 0.642047005471886 -1.36071500477977 4.21201603890795
SRP54 0.014073 Protein export_Homo sapiens_hsa03060 0.197019700730107 0.026299014489004 0.368186202846052 -0.927630765715449 3.95496200805887
SRP14 0.014073 Protein export_Homo sapiens_hsa03060 0.197019700730107 0.026299014489004 0.368186202846052 -0.927630765715449 3.95496200805887
ITGB1 0.077569 Proteoglycans in cancer_Homo sapiens_hsa05205 0.434385062240191 0.158756393829573 0.793781969147868 -1.39214128824509 3.55913518634233
SDC2 0.077569 Proteoglycans in cancer_Homo sapiens_hsa05205 0.434385062240191 0.158756393829573 0.793781969147868 -1.39214128824509 3.55913518634233
RDX 0.077569 Proteoglycans in cancer_Homo sapiens_hsa05205 0.434385062240191 0.158756393829573 0.793781969147868 -1.39214128824509 3.55913518634233
RAC1 0.077569 Proteoglycans in cancer_Homo sapiens_hsa05205 0.434385062240191 0.158756393829573 0.793781969147868 -1.39214128824509 3.55913518634233
SMS 0.024824 beta-Alanine metabolism_Homo sapiens_hsa00410 0.231693307611595 0.043947014503062 0.439470145030622 -0.927300472574533 3.42724037421705
SRM 0.024824 beta-Alanine metabolism_Homo sapiens_hsa00410 0.231693307611595 0.043947014503062 0.439470145030622 -0.927300472574533 3.42724037421705
TKTL1 0.060429 Carbon metabolism_Homo sapiens_hsa01200 0.358644929916591 0.113683094181396 0.691984051538935 -1.14303901192518 3.20770315167122
ENO1 0.060429 Carbon metabolism_Homo sapiens_hsa01200 0.358644929916591 0.113683094181396 0.691984051538935 -1.14303901192518 3.20770315167122
ALDOA 0.060429 Carbon metabolism_Homo sapiens_hsa01200 0.358644929916591 0.113683094181396 0.691984051538935 -1.14303901192518 3.20770315167122
TKTL1 0.021898 Pentose phosphate pathway_Homo sapiens_hsa00030 0.218977995149795 0.03920720759137 0.439470145030622 -0.783262792235005 2.99313625177265
ALDOA 0.021898 Pentose phosphate pathway_Homo sapiens_hsa00030 0.218977995149795 0.03920720759137 0.439470145030622 -0.783262792235005 2.99313625177265
SNAP29 0.029493 SNARE interactions in vesicular transport_Homo sapiens_hsa04130 0.242884933959828 0.051431162723194 0.480024185416474 -0.801756493425037 2.82506641348389
VAMP2 0.029493 SNARE interactions in vesicular transport_Homo sapiens_hsa04130 0.242884933959828 0.051431162723194 0.480024185416474 -0.801756493425037 2.82506641348389
HSPB1 0.083911 VEGF signaling pathway_Homo sapiens_hsa04370 0.451826661862574 0.134219187253514 0.75162744861968 -1.06037310751514 2.62760726304196
RAC1 0.083911 VEGF signaling pathway_Homo sapiens_hsa04370 0.451826661862574 0.134219187253514 0.75162744861968 -1.06037310751514 2.62760726304196
UXS1 0.055225 Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 0.351433069411 0.091420410056403 0.63994287039482 -0.864560901563793 2.50405883685565
UAP1 0.055225 Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 0.351433069411 0.091420410056403 0.63994287039482 -0.864560901563793 2.50405883685565
RAC1 0.061482 Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 0.358644929916591 0.100893100859867 0.642047005471886 -0.833662333174372 2.32509343864079
SOD1 0.061482 Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 0.358644929916591 0.100893100859867 0.642047005471886 -0.833662333174372 2.32509343864079
ITGB1 0.093481 Shigellosis_Homo sapiens_hsa05131 0.484715459847644 0.148172008214671 0.768299301853852 -0.803462980237357 1.90420629703093
RAC1 0.093481 Shigellosis_Homo sapiens_hsa05131 0.484715459847644 0.148172008214671 0.768299301853852 -0.803462980237357 1.90420629703093
ITGB1 0.126498 Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 0.610680719948045 0.195247866205581 0.796020367692396 -0.915168957714572 1.89213708083241
RAC1 0.126498 Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 0.610680719948045 0.195247866205581 0.796020367692396 -0.915168957714572 1.89213708083241
ATP1B3 0.145263 Insulin secretion_Homo sapiens_hsa04911 0.627837283117441 0.221338992850997 0.796020367692396 -0.973268187226535 1.87763504649134
VAMP2 0.145263 Insulin secretion_Homo sapiens_hsa04911 0.627837283117441 0.221338992850997 0.796020367692396 -0.973268187226535 1.87763504649134
NME3 0.162941 Purine metabolism_Homo sapiens_hsa00230 0.650845903085116 0.273766260825587 0.796020367692396 -0.994203956613994 1.80384818005705
AK5 0.162941 Purine metabolism_Homo sapiens_hsa00230 0.650845903085116 0.273766260825587 0.796020367692396 -0.994203956613994 1.80384818005705
POLR2L 0.162941 Purine metabolism_Homo sapiens_hsa00230 0.650845903085116 0.273766260825587 0.796020367692396 -0.994203956613994 1.80384818005705
ITGB1 0.147990 Small cell lung cancer_Homo sapiens_hsa05222 0.627837283117441 0.225092972099928 0.796020367692396 -0.887741245104553 1.69612651070421
CKS1B 0.147990 Small cell lung cancer_Homo sapiens_hsa05222 0.627837283117441 0.225092972099928 0.796020367692396 -0.887741245104553 1.69612651070421
LYPLA1 0.189970 Choline metabolism in cancer_Homo sapiens_hsa05231 0.650845903085116 0.28176471687755 0.796020367692396 -0.923596627193157 1.53399360275466
RAC1 0.189970 Choline metabolism in cancer_Homo sapiens_hsa05231 0.650845903085116 0.28176471687755 0.796020367692396 -0.923596627193157 1.53399360275466
DYNC1LI1 0.147990 Salmonella infection_Homo sapiens_hsa05132 0.627837283117441 0.225092972099928 0.796020367692396 -0.80189632023203 1.53211041514863
RAC1 0.147990 Salmonella infection_Homo sapiens_hsa05132 0.627837283117441 0.225092972099928 0.796020367692396 -0.80189632023203 1.53211041514863
HSPB1 0.214595 Epstein-Barr virus infection_Homo sapiens_hsa05169 0.650845903085116 0.346482438869677 0.796020367692396 -0.935310267928547 1.43944530558886
RAN 0.214595 Epstein-Barr virus infection_Homo sapiens_hsa05169 0.650845903085116 0.346482438869677 0.796020367692396 -0.935310267928547 1.43944530558886
POLR2L 0.214595 Epstein-Barr virus infection_Homo sapiens_hsa05169 0.650845903085116 0.346482438869677 0.796020367692396 -0.935310267928547 1.43944530558886
ENO1 0.195689 HIF-1 signaling pathway_Homo sapiens_hsa04066 0.650845903085116 0.289329143940097 0.796020367692396 -0.821056253782842 1.33933107366522
ALDOA 0.195689 HIF-1 signaling pathway_Homo sapiens_hsa04066 0.650845903085116 0.289329143940097 0.796020367692396 -0.821056253782842 1.33933107366522
ATP1B3 0.175780 Pancreatic secretion_Homo sapiens_hsa04972 0.650845903085116 0.262838747283006 0.796020367692396 -0.763041721207036 1.32656426870378
RAC1 0.175780 Pancreatic secretion_Homo sapiens_hsa04972 0.650845903085116 0.262838747283006 0.796020367692396 -0.763041721207036 1.32656426870378
ITGB1 0.233237 Rap1 signaling pathway_Homo sapiens_hsa04015 0.650845903085116 0.371663285774214 0.796020367692396 -0.805494293835518 1.17255856614673
ID1 0.233237 Rap1 signaling pathway_Homo sapiens_hsa04015 0.650845903085116 0.371663285774214 0.796020367692396 -0.805494293835518 1.17255856614673
RAC1 0.233237 Rap1 signaling pathway_Homo sapiens_hsa04015 0.650845903085116 0.371663285774214 0.796020367692396 -0.805494293835518 1.17255856614673
NME3 0.201430 Pyrimidine metabolism_Homo sapiens_hsa00240 0.650845903085116 0.296885802787212 0.796020367692396 -0.724886165925883 1.161495766794
POLR2L 0.201430 Pyrimidine metabolism_Homo sapiens_hsa00240 0.650845903085116 0.296885802787212 0.796020367692396 -0.724886165925883 1.161495766794
ITGB1 0.239517 Regulation of actin cytoskeleton_Homo sapiens_hsa04810 0.650845903085116 0.38002601348172 0.796020367692396 -0.733758665131601 1.04863854411104
RDX 0.239517 Regulation of actin cytoskeleton_Homo sapiens_hsa04810 0.650845903085116 0.38002601348172 0.796020367692396 -0.733758665131601 1.04863854411104
RAC1 0.239517 Regulation of actin cytoskeleton_Homo sapiens_hsa04810 0.650845903085116 0.38002601348172 0.796020367692396 -0.733758665131601 1.04863854411104
ITGB1 0.239134 Leukocyte transendothelial migration_Homo sapiens_hsa04670 0.650845903085116 0.345635181731086 0.796020367692396 -0.521185746975972 0.745676790724311
RAC1 0.239134 Leukocyte transendothelial migration_Homo sapiens_hsa04670 0.650845903085116 0.345635181731086 0.796020367692396 -0.521185746975972 0.745676790724311
CPEB1 0.253746 Oocyte meiosis_Homo sapiens_hsa04114 0.650845903085116 0.364127848905809 0.796020367692396 -0.53257585949883 0.730386546993152
SKP1 0.253746 Oocyte meiosis_Homo sapiens_hsa04114 0.650845903085116 0.364127848905809 0.796020367692396 -0.53257585949883 0.730386546993152
GALNS 0.253746 Lysosome_Homo sapiens_hsa04142 0.650845903085116 0.364127848905809 0.796020367692396 -0.518521976613411 0.711112734991634
AP3D1 0.253746 Lysosome_Homo sapiens_hsa04142 0.650845903085116 0.364127848905809 0.796020367692396 -0.518521976613411 0.711112734991634
ITGB1 0.265451 Axon guidance_Homo sapiens_hsa04360 0.650845903085116 0.378785672838693 0.796020367692396 -0.440516510012417 0.584267444668773
RAC1 0.265451 Axon guidance_Homo sapiens_hsa04360 0.650845903085116 0.378785672838693 0.796020367692396 -0.440516510012417 0.584267444668773
BNIP3 0.283008 FoxO signaling pathway_Homo sapiens_hsa04068 0.650845903085116 0.400512914261181 0.796020367692396 -0.403060412555883 0.508774454624571
FBXO25 0.283008 FoxO signaling pathway_Homo sapiens_hsa04068 0.650845903085116 0.400512914261181 0.796020367692396 -0.403060412555883 0.508774454624571
RPL27 0.294696 Ribosome_Homo sapiens_hsa03010 0.650845903085116 0.414806828003123 0.796020367692396 -0.340201291698115 0.415661753400168
UBA52 0.294696 Ribosome_Homo sapiens_hsa03010 0.650845903085116 0.414806828003123 0.796020367692396 -0.340201291698115 0.415661753400168
ID1 0.309267 Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 0.650845903085116 0.432440290221677 0.796020367692396 -0.257329198334649 0.301988383574837
ID4 0.309267 Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 0.650845903085116 0.432440290221677 0.796020367692396 -0.257329198334649 0.301988383574837
RAC1 0.309267 Wnt signaling pathway_Homo sapiens_hsa04310 0.650845903085116 0.432440290221677 0.796020367692396 -0.254266570150932 0.298394239806166
SKP1 0.309267 Wnt signaling pathway_Homo sapiens_hsa04310 0.650845903085116 0.432440290221677 0.796020367692396 -0.254266570150932 0.298394239806166
UBE2E2 0.294696 Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 0.650845903085116 0.414806828003123 0.796020367692396 -0.241887944833481 0.295541403661298
SKP1 0.294696 Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 0.650845903085116 0.414806828003123 0.796020367692396 -0.241887944833481 0.295541403661298
ITGB1 0.309267 Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 0.650845903085116 0.432440290221677 0.796020367692396 -0.233259126905489 0.27374097904218
SDC2 0.309267 Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 0.650845903085116 0.432440290221677 0.796020367692396 -0.233259126905489 0.27374097904218
CREM 0.326673 Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 0.656469699135545 0.453232919532676 0.796020367692396 -0.160439608673768 0.179499028508343
ATP1B3 0.326673 Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 0.656469699135545 0.453232919532676 0.796020367692396 -0.160439608673768 0.179499028508343
ITGB1 0.383677 Pathways in cancer_Homo sapiens_hsa05200 0.656469699135545 0.588445480325383 0.796020367692396 -0.134467304633648 0.128813480470061
GSTP1 0.383677 Pathways in cancer_Homo sapiens_hsa05200 0.656469699135545 0.588445480325383 0.796020367692396 -0.134467304633648 0.128813480470061
RAC1 0.383677 Pathways in cancer_Homo sapiens_hsa05200 0.656469699135545 0.588445480325383 0.796020367692396 -0.134467304633648 0.128813480470061
CKS1B 0.383677 Pathways in cancer_Homo sapiens_hsa05200 0.656469699135545 0.588445480325383 0.796020367692396 -0.134467304633648 0.128813480470061
RDX 0.906827 MicroRNAs in cancer_Homo sapiens_hsa05206 0.906826644229066 0.955452736356557 0.955452736356557 1.44933645125233 -0.14175087051471
RAC1 0.836462 Ras signaling pathway_Homo sapiens_hsa04014 0.842480053306569 0.906351951930132 0.912872469569917 1.56085632265796 -0.278728016875166
RAC1 0.804914 Viral carcinogenesis_Homo sapiens_hsa05203 0.816579175422802 0.881905999447701 0.894687245816509 1.50268841729681 -0.326113649853584
SOD1 0.451933 Huntingtons disease_Homo sapiens_hsa05016 0.656469699135545 0.594330457559716 0.796020367692396 0.45466153218911 -0.361101937897525
POLR2L 0.451933 Huntingtons disease_Homo sapiens_hsa05016 0.656469699135545 0.594330457559716 0.796020367692396 0.45466153218911 -0.361101937897525
SKP1 0.771020 Herpes simplex infection_Homo sapiens_hsa05168 0.791620827654646 0.854280048252367 0.88252217688804 1.44082614353668 -0.374673195380874
ITGB1 0.754095 PI3K-Akt signaling pathway_Homo sapiens_hsa04151 0.782024393752772 0.870565837869122 0.889629323369906 1.40713825060957 -0.397146463010796
RAC1 0.754095 PI3K-Akt signaling pathway_Homo sapiens_hsa04151 0.782024393752772 0.870565837869122 0.889629323369906 1.40713825060957 -0.397146463010796
ITGB1 0.475445 Focal adhesion_Homo sapiens_hsa04510 0.656469699135545 0.619152897895429 0.796020367692396 0.542252996718075 -0.403166886995017
RAC1 0.475445 Focal adhesion_Homo sapiens_hsa04510 0.656469699135545 0.619152897895429 0.796020367692396 0.542252996718075 -0.403166886995017
RAC1 0.774658 Chemokine signaling pathway_Homo sapiens_hsa04062 0.791620827654646 0.857307257548381 0.88252217688804 1.59944949336402 -0.408394239278505
ATP1B3 0.467675 cAMP signaling pathway_Homo sapiens_hsa04024 0.656469699135545 0.611007742574492 0.796020367692396 0.562678353796488 -0.427625590926902
RAC1 0.467675 cAMP signaling pathway_Homo sapiens_hsa04024 0.656469699135545 0.611007742574492 0.796020367692396 0.562678353796488 -0.427625590926902
ATP1B3 0.735546 cGMP-PKG signaling pathway_Homo sapiens_hsa04022 0.768481041040048 0.824023846471974 0.86092043661251 1.51527341611193 -0.46540412128575
FHL1 0.715812 Jak-STAT signaling pathway_Homo sapiens_hsa04630 0.753486795876249 0.806651480435107 0.849106821510639 1.42496262212177 -0.476417841017517
HSPB1 0.600728 MAPK signaling pathway_Homo sapiens_hsa04010 0.705784830713475 0.742332507120205 0.831397956825052 0.95554283083622 -0.486957176741912
RAC1 0.600728 MAPK signaling pathway_Homo sapiens_hsa04010 0.705784830713475 0.742332507120205 0.831397956825052 0.95554283083622 -0.486957176741912
CREM 0.607111 HTLV-I infection_Homo sapiens_hsa05166 0.705784830713475 0.748186004954079 0.831397956825052 0.979656896251826 -0.4888918207165
RAN 0.607111 HTLV-I infection_Homo sapiens_hsa05166 0.705784830713475 0.748186004954079 0.831397956825052 0.979656896251826 -0.4888918207165
ID1 0.704224 Hippo signaling pathway_Homo sapiens_hsa04390 0.746904302237362 0.796280412727543 0.844539831680727 1.41468840352817 -0.496072812802772
RAC1 0.699458 Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 0.746904302237362 0.791980066435169 0.844539831680727 1.39516888543326 -0.498701869618938
LAMTOR5 0.687207 Hepatitis B_Homo sapiens_hsa05161 0.740069555816997 0.78083365821175 0.8408977857665 1.3517097876028 -0.507052125204204
TUBA1B 0.671850 Apoptosis_Homo sapiens_hsa04210 0.729139365121289 0.76667844095015 0.832054121961403 1.32876300393009 -0.528476167362296
YBX3 0.669218 Tight junction_Homo sapiens_hsa04530 0.729139365121289 0.764233149495028 0.832054121961403 1.32674109084191 -0.532878719072459
EIF4A3 0.655743 Spliceosome_Homo sapiens_hsa03040 0.725884772757831 0.751622487251802 0.831397956825052 1.28459487783641 -0.542081065938005
RAC1 0.658481 Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 0.725884772757831 0.754196717977011 0.831397956825052 1.3564772995805 -0.56676243391295
RAC1 0.650202 Osteoclast differentiation_Homo sapiens_hsa04380 0.725884772757831 0.746394012467336 0.831397956825052 1.34522767757966 -0.579083807053495
ITGB1 0.621136 Platelet activation_Homo sapiens_hsa04611 0.70698402951757 0.718579050120864 0.831247335750937 1.30306669771437 -0.620527228172186
RAC1 0.615041 Neurotrophin signaling pathway_Homo sapiens_hsa04722 0.705784830713475 0.712665367497463 0.831247335750937 1.30075926050665 -0.632255160529657
SKP1 0.627135 Cell cycle_Homo sapiens_hsa04110 0.708055615508318 0.724372678297245 0.831247335750937 1.37621930952356 -0.642134973938858
RAC1 0.615041 Sphingolipid signaling pathway_Homo sapiens_hsa04071 0.705784830713475 0.712665367497463 0.831247335750937 1.32956641622124 -0.646257346340456
ATP1B3 0.608849 Thyroid hormone signaling pathway_Homo sapiens_hsa04919 0.705784830713475 0.706629178438503 0.831247335750937 1.30486614137782 -0.647455539817053
KCNQ2 0.586386 Cholinergic synapse_Homo sapiens_hsa04725 0.705784830713475 0.684501208635465 0.826122148353148 1.22253897543091 -0.652563446928119
RAC1 0.569561 Toll-like receptor signaling pathway_Homo sapiens_hsa04620 0.693378151120201 0.667695754541702 0.812847005529029 1.19744162112087 -0.674027974285757
RAC1 0.552055 AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 0.677962832573775 0.650008218615616 0.79825570707181 1.14202402509858 -0.678484223054012
ITGB1 0.608849 Toxoplasmosis_Homo sapiens_hsa05145 0.705784830713475 0.706629178438503 0.831247335750937 1.38279712485099 -0.686123756711559
CPEB1 0.541215 Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 0.677962832573775 0.638953418152198 0.79825570707181 1.13737257451531 -0.698277690400512
LDHB 0.552055 Glucagon signaling pathway_Homo sapiens_hsa04922 0.677962832573775 0.650008218615616 0.79825570707181 1.24882041582766 -0.741932683503461
HSPB1 0.548470 Amoebiasis_Homo sapiens_hsa05146 0.677962832573775 0.646360887850298 0.79825570707181 1.24802107469397 -0.749588778617188
RAC1 0.417393 Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 0.656469699135545 0.507623522082223 0.796020367692396 0.893642871432345 -0.78080021368661
RAC1 0.522564 Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 0.671183633108016 0.619758714846223 0.796020367692396 1.20480863366554 -0.781929295980929
RAC1 0.440123 B cell receptor signaling pathway_Homo sapiens_hsa04662 0.656469699135545 0.532392036871052 0.796020367692396 0.965812314928246 -0.792642263535658
LYPLA1 0.530113 Glycerophospholipid metabolism_Homo sapiens_hsa00564 0.674689573870772 0.627554442320935 0.79825570707181 1.26744283404206 -0.804401151598061
GSTP1 0.507103 Prostate cancer_Homo sapiens_hsa05215 0.662426363127028 0.603681405847885 0.796020367692396 1.18792222075138 -0.806647276551115
RAC1 0.408046 Pancreatic cancer_Homo sapiens_hsa05212 0.656469699135545 0.497357785936434 0.796020367692396 0.945021819358468 -0.847094292362176
TUBA1B 0.503161 Gap junction_Homo sapiens_hsa04540 0.662426363127028 0.599558455583978 0.796020367692396 1.2569039182836 -0.863298374836231
RAC1 0.408046 Renal cell carcinoma_Homo sapiens_hsa05211 0.656469699135545 0.497357785936434 0.796020367692396 0.980854514732183 -0.879213838291425
ITGB1 0.511015 Dilated cardiomyopathy_Homo sapiens_hsa05414 0.662426363127028 0.607762489764317 0.796020367692396 1.31082238671859 -0.880029880483725
ITGB1 0.440123 Leishmaniasis_Homo sapiens_hsa05140 0.656469699135545 0.532392036871052 0.796020367692396 1.07618728859854 -0.883227015474978
SOD1 0.398550 Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 0.656469699135545 0.486881049432589 0.796020367692396 0.979779365856841 -0.901320610854866
RAN 0.507103 Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 0.662426363127028 0.603681405847885 0.796020367692396 1.32933639081378 -0.90267322265592
RAC1 0.388903 Colorectal cancer_Homo sapiens_hsa05210 0.656469699135545 0.47618903803931 0.796020367692396 0.989294905903886 -0.934315426028438
GSTP1 0.478840 Chemical carcinogenesis_Homo sapiens_hsa05204 0.656469699135545 0.57391755374814 0.796020367692396 1.28385701315101 -0.945417823099695
RAC1 0.417393 Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 0.656469699135545 0.507623522082223 0.796020367692396 1.0844262949664 -0.947492907854802
ATP1B3 0.431139 Bile secretion_Homo sapiens_hsa04976 0.656469699135545 0.522635645669318 0.796020367692396 1.12979442726202 -0.950524202763736
ATP1B3 0.444563 Gastric acid secretion_Homo sapiens_hsa04971 0.656469699135545 0.537196228267169 0.796020367692396 1.17794219602671 -0.95491568794022
RAC1 0.444563 Adherens junction_Homo sapiens_hsa04520 0.656469699135545 0.537196228267169 0.796020367692396 1.18914973054217 -0.96400123608345
PIN1 0.426593 RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 0.656469699135545 0.517682448743549 0.796020367692396 1.14495735646279 -0.975417401358388
ITGB1 0.478840 ECM-receptor interaction_Homo sapiens_hsa04512 0.656469699135545 0.57391755374814 0.796020367692396 1.32568176437051 -0.976217098131555
GSTP1 0.440123 Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 0.656469699135545 0.532392036871052 0.796020367692396 1.20092831726561 -0.985601990188131
ATP1B3 0.431139 Thyroid hormone synthesis_Homo sapiens_hsa04918 0.656469699135545 0.522635645669318 0.796020367692396 1.17228212548119 -0.986270161942266
GSTP1 0.422011 Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 0.656469699135545 0.512678577894764 0.796020367692396 1.14800832789716 -0.990413738349282
ATP1B3 0.511015 Protein digestion and absorption_Homo sapiens_hsa04974 0.662426363127028 0.607762489764317 0.796020367692396 1.47952096729794 -0.993286865723857
ATP1B3 0.461973 Cardiac muscle contraction_Homo sapiens_hsa04260 0.656469699135545 0.555931038282215 0.796020367692396 1.29783859647215 -1.00225571177392
SOD1 0.482974 Peroxisome_Homo sapiens_hsa04146 0.656469699135545 0.578300742218329 0.796020367692396 1.40167254234449 -1.02012630941796
ITGB1 0.448967 Pertussis_Homo sapiens_hsa05133 0.656469699135545 0.541951740125183 0.796020367692396 1.28874438809616 -1.03203439831923
CPEB1 0.192883 Dorso-ventral axis formation_Homo sapiens_hsa04320 0.650845903085116 0.249242002092303 0.796020367692396 0.629089795415532 -1.03527453094904
POLR2L 0.398550 Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 0.656469699135545 0.486881049432589 0.796020367692396 1.13683951868446 -1.04580370349864
RAC1 0.374143 Viral myocarditis_Homo sapiens_hsa05416 0.656469699135545 0.459737819518782 0.796020367692396 1.07777092879158 -1.05957505994167
ITGB1 0.482974 Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 0.656469699135545 0.578300742218329 0.796020367692396 1.45632133993132 -1.05989927672111
BNIP3 0.353911 Legionellosis_Homo sapiens_hsa05134 0.656469699135545 0.437007972708219 0.796020367692396 1.02750767501084 -1.06728290085673
KRT10 0.359029 Staphylococcus aureus infection_Homo sapiens_hsa05150 0.656469699135545 0.442777318851076 0.796020367692396 1.04421826559608 -1.06964726500929
ITGB1 0.444563 Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 0.656469699135545 0.537196228267169 0.796020367692396 1.35743369503989 -1.10042303867248
PTGES3 0.388903 Arachidonic acid metabolism_Homo sapiens_hsa00590 0.656469699135545 0.47618903803931 0.796020367692396 1.17101548898404 -1.10593699507265
VAMP2 0.393746 Synaptic vesicle cycle_Homo sapiens_hsa04721 0.656469699135545 0.481562223576996 0.796020367692396 1.2328319726414 -1.14906144144964
UXS1 0.359029 Starch and sucrose metabolism_Homo sapiens_hsa00500 0.656469699135545 0.442777318851076 0.796020367692396 1.16035783908543 -1.18861509121497
ATP1B3 0.266273 Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 0.650845903085116 0.336271160622352 0.796020367692396 0.904353533851182 -1.19666912047004
SDC2 0.322338 Malaria_Homo sapiens_hsa05144 0.656469699135545 0.401134123121085 0.796020367692396 1.15760453384394 -1.31058854286796
ATP1B3 0.300442 Carbohydrate digestion and absorption_Homo sapiens_hsa04973 0.650845903085116 0.375975456142454 0.796020367692396 1.10179876602199 -1.32491402656483
TAF9 0.300442 Basal transcription factors_Homo sapiens_hsa03022 0.650845903085116 0.375975456142454 0.796020367692396 1.10846565236039 -1.33293096350074
ATP1B3 0.311476 Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 0.650845903085116 0.388682404032517 0.796020367692396 1.18342088155171 -1.38038019401852
SOD1 0.242578 Prion diseases_Homo sapiens_hsa05020 0.650845903085116 0.308428176019319 0.796020367692396 0.982303119239946 -1.39136427154981
ATP1B3 0.333029 Mineral absorption_Homo sapiens_hsa04978 0.656469699135545 0.413335669103216 0.796020367692396 1.33244611102817 -1.46505963316019
LDHB 0.224309 Propanoate metabolism_Homo sapiens_hsa00640 0.650845903085116 0.286793058279441 0.796020367692396 0.99674066332682 -1.48985714219745
ALDOA 0.224309 Fructose and mannose metabolism_Homo sapiens_hsa00051 0.650845903085116 0.286793058279441 0.796020367692396 1.01519335260774 -1.51743891138722
RAD23A 0.311476 Nucleotide excision repair_Homo sapiens_hsa03420 0.650845903085116 0.388682404032517 0.796020367692396 1.37540926821402 -1.60432162564404
UROS 0.283560 Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 0.650845903085116 0.356425172719484 0.796020367692396 1.30667046989025 -1.64683781128185
NEIL2 0.230447 Base excision repair_Homo sapiens_hsa03410 0.650845903085116 0.294077907163925 0.796020367692396 1.19226921524751 -1.74993364599556
ATP1B3 0.166834 Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 0.650845903085116 0.217803146396004 0.796020367692396 0.98894289062005 -1.77095564881136
LDHB 0.272081 Pyruvate metabolism_Homo sapiens_hsa00620 0.650845903085116 0.343057368579731 0.796020367692396 1.36711791607685 -1.77951549118748
ATG3 0.266273 Regulation of autophagy_Homo sapiens_hsa04140 0.650845903085116 0.336271160622352 0.796020367692396 1.35898680647569 -1.79825420652724
SKP1 0.211888 Circadian rhythm_Homo sapiens_hsa04710 0.650845903085116 0.272000250645794 0.796020367692396 1.17439501182362 -1.82230833074343
POLR2L 0.224309 RNA polymerase_Homo sapiens_hsa03020 0.650845903085116 0.286793058279441 0.796020367692396 1.2384743138203 -1.85118343192172
GALNS 0.139949 Glycosaminoglycan degradation_Homo sapiens_hsa00531 0.627837283117441 0.185066789813652 0.796020367692396 1.66824270562412 -3.28055539384317
PTS 0.105129 Folate biosynthesis_Homo sapiens_hsa00790 0.525643778515686 0.142241150889711 0.765913889406138 1.81520039540581 -4.08886492955739
PDXK 0.046479 Vitamin B6 metabolism_Homo sapiens_hsa00750 0.309862321356538 0.069060552031093 0.537137626908502 2.62244073501331 -8.04760763572092

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