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Table S4: KEGG Up in Human SCT

HERMANN, Brian P., et al. The mammalian spermatogenesis single-cell transcriptome, from spermatogonial stem cells to spermatids. Cell reports, 2018, 25. Jg., Nr. 6, S. 1650-1667. e8.

Publication: https://doi.org/10.1016/j.celrep.2018.10.026

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The publication The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to Spermatids by Brian P. Hermann, Keren Cheng, Anukriti Singh, Lorena Roa-De La Cruz, Kazadi N. Mutoji, I-Chung Chen, Heidi Gildersleeve, Jake D. Lehle, Max Mayo, Birgit Westernströer, Nathan C. Law, Melissa J. Oatley, Ellen K. Velte, Bryan A. Niedenberger, Danielle Fritze, Sherman Silber, Christopher B. Geyer, Jon M. Oatley, John R. McCarrey is published under an open access no derivatives license: : https://creativecommons.org/licenses/by-nc-nd/4.0/. Granted rights: share — copy and redistribute the material in any medium or format. No alterations allowed. Thus, tables can not be shown in MFGA format.

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Table

GENE PVALUE Term Adjusted.p.value Old.p.value Old.adjusted.p.value Z.score Combined.score
BTG3 0.008238 RNA degradation_Homo sapiens_hsa03018 0.347754096981637 0.00744408255854 0.338219319725382 -1.83920238457436 8.82639670439471
BTG1 0.008238 RNA degradation_Homo sapiens_hsa03018 0.347754096981637 0.00744408255854 0.338219319725382 -1.83920238457436 8.82639670439471
PABPC1 0.008238 RNA degradation_Homo sapiens_hsa03018 0.347754096981637 0.00744408255854 0.338219319725382 -1.83920238457436 8.82639670439471
ENO1 0.008238 RNA degradation_Homo sapiens_hsa03018 0.347754096981637 0.00744408255854 0.338219319725382 -1.83920238457436 8.82639670439471
TPR 0.008917 RNA transport_Homo sapiens_hsa03013 0.347754096981637 0.007003455941302 0.338219319725382 -1.81864665332374 8.58368346434271
EIF3J 0.008917 RNA transport_Homo sapiens_hsa03013 0.347754096981637 0.007003455941302 0.338219319725382 -1.81864665332374 8.58368346434271
SAP18 0.008917 RNA transport_Homo sapiens_hsa03013 0.347754096981637 0.007003455941302 0.338219319725382 -1.81864665332374 8.58368346434271
PABPC1 0.008917 RNA transport_Homo sapiens_hsa03013 0.347754096981637 0.007003455941302 0.338219319725382 -1.81864665332374 8.58368346434271
RAN 0.008917 RNA transport_Homo sapiens_hsa03013 0.347754096981637 0.007003455941302 0.338219319725382 -1.81864665332374 8.58368346434271
KPNB1 0.008917 RNA transport_Homo sapiens_hsa03013 0.347754096981637 0.007003455941302 0.338219319725382 -1.81864665332374 8.58368346434271
DYNC1LI1 0.010459 Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 0.347754096981637 0.010172009615801 0.338219319725382 -1.84737684609278 8.4246192961828
GNAS 0.010459 Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 0.347754096981637 0.010172009615801 0.338219319725382 -1.84737684609278 8.4246192961828
DYNLL1 0.010459 Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 0.347754096981637 0.010172009615801 0.338219319725382 -1.84737684609278 8.4246192961828
XRCC6 0.007642 Non-homologous end-joining_Homo sapiens_hsa03450 0.347754096981637 0.008809295448936 0.338219319725382 -1.49110067862704 7.26774908292495
XRCC5 0.007642 Non-homologous end-joining_Homo sapiens_hsa03450 0.347754096981637 0.008809295448936 0.338219319725382 -1.49110067862704 7.26774908292495
TKTL2 0.029522 Carbon metabolism_Homo sapiens_hsa01200 0.681002927307545 0.025676282513115 0.622843743837178 -1.60874761169098 5.66700639521594
TKTL1 0.029522 Carbon metabolism_Homo sapiens_hsa01200 0.681002927307545 0.025676282513115 0.622843743837178 -1.60874761169098 5.66700639521594
ENO1 0.029522 Carbon metabolism_Homo sapiens_hsa01200 0.681002927307545 0.025676282513115 0.622843743837178 -1.60874761169098 5.66700639521594
ACAT1 0.029522 Carbon metabolism_Homo sapiens_hsa01200 0.681002927307545 0.025676282513115 0.622843743837178 -1.60874761169098 5.66700639521594
DBF4 0.039476 Cell cycle_Homo sapiens_hsa04110 0.681002927307545 0.034182463273269 0.622843743837178 -1.58151942516914 5.11156154247858
PTTG1 0.039476 Cell cycle_Homo sapiens_hsa04110 0.681002927307545 0.034182463273269 0.622843743837178 -1.58151942516914 5.11156154247858
SMC3 0.039476 Cell cycle_Homo sapiens_hsa04110 0.681002927307545 0.034182463273269 0.622843743837178 -1.58151942516914 5.11156154247858
SKP1 0.039476 Cell cycle_Homo sapiens_hsa04110 0.681002927307545 0.034182463273269 0.622843743837178 -1.58151942516914 5.11156154247858
TKTL2 0.040963 Biosynthesis of amino acids_Homo sapiens_hsa01230 0.681002927307545 0.03746428534359 0.622843743837178 -1.54614456661351 4.94008072350666
TKTL1 0.040963 Biosynthesis of amino acids_Homo sapiens_hsa01230 0.681002927307545 0.03746428534359 0.622843743837178 -1.54614456661351 4.94008072350666
ENO1 0.040963 Biosynthesis of amino acids_Homo sapiens_hsa01230 0.681002927307545 0.03746428534359 0.622843743837178 -1.54614456661351 4.94008072350666
MRPS15 0.053423 Ribosome_Homo sapiens_hsa03010 0.769646451429668 0.046128200119272 0.681672290651465 -1.55221573768695 4.54724692458311
RPL27 0.053423 Ribosome_Homo sapiens_hsa03010 0.769646451429668 0.046128200119272 0.681672290651465 -1.55221573768695 4.54724692458311
MRPL34 0.053423 Ribosome_Homo sapiens_hsa03010 0.769646451429668 0.046128200119272 0.681672290651465 -1.55221573768695 4.54724692458311
UBA52 0.053423 Ribosome_Homo sapiens_hsa03010 0.769646451429668 0.046128200119272 0.681672290651465 -1.55221573768695 4.54724692458311
TKTL2 0.035724 Pentose phosphate pathway_Homo sapiens_hsa00030 0.681002927307545 0.035357094277597 0.622843743837178 -1.25772654793742 4.19066722445581
TKTL1 0.035724 Pentose phosphate pathway_Homo sapiens_hsa00030 0.681002927307545 0.035357094277597 0.622843743837178 -1.25772654793742 4.19066722445581
GNAS 0.084433 Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 0.769646451429668 0.080159598475801 0.773619234103383 -1.51705500488025 3.74985722413531
CLTA 0.084433 Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 0.769646451429668 0.080159598475801 0.773619234103383 -1.51705500488025 3.74985722413531
BCAP31 0.097533 Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 0.769646451429668 0.084229986280474 0.773619234103383 -1.50395175820696 3.50053876198982
BAG2 0.097533 Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 0.769646451429668 0.084229986280474 0.773619234103383 -1.50395175820696 3.50053876198982
SSR3 0.097533 Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 0.769646451429668 0.084229986280474 0.773619234103383 -1.50395175820696 3.50053876198982
SKP1 0.097533 Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 0.769646451429668 0.084229986280474 0.773619234103383 -1.50395175820696 3.50053876198982
GNAS 0.097008 Vibrio cholerae infection_Homo sapiens_hsa05110 0.769646451429668 0.091692680753114 0.773619234103383 -1.43068214119553 3.3377204633977
KDELR2 0.097008 Vibrio cholerae infection_Homo sapiens_hsa05110 0.769646451429668 0.091692680753114 0.773619234103383 -1.43068214119553 3.3377204633977
TECR 0.087527 Fatty acid metabolism_Homo sapiens_hsa01212 0.769646451429668 0.082997612707983 0.773619234103383 -1.35773632006249 3.30717949926053
ACAT1 0.087527 Fatty acid metabolism_Homo sapiens_hsa01212 0.769646451429668 0.082997612707983 0.773619234103383 -1.35773632006249 3.30717949926053
PTTG1 0.133951 Oocyte meiosis_Homo sapiens_hsa04114 0.798304893619517 0.120383943660469 0.773619234103383 -1.40686536691975 2.82819291044233
SMC3 0.133951 Oocyte meiosis_Homo sapiens_hsa04114 0.798304893619517 0.120383943660469 0.773619234103383 -1.40686536691975 2.82819291044233
SKP1 0.133951 Oocyte meiosis_Homo sapiens_hsa04114 0.798304893619517 0.120383943660469 0.773619234103383 -1.40686536691975 2.82819291044233
CTSL 0.133951 Lysosome_Homo sapiens_hsa04142 0.798304893619517 0.120383943660469 0.773619234103383 -1.34754314552676 2.70893865206033
CLTA 0.133951 Lysosome_Homo sapiens_hsa04142 0.798304893619517 0.120383943660469 0.773619234103383 -1.34754314552676 2.70893865206033
CTSF 0.133951 Lysosome_Homo sapiens_hsa04142 0.798304893619517 0.120383943660469 0.773619234103383 -1.34754314552676 2.70893865206033
TUBA1B 0.175532 Apoptosis_Homo sapiens_hsa04210 0.798304893619517 0.157918396633157 0.773619234103383 -1.47289669901849 2.56273996879313
CTSL 0.175532 Apoptosis_Homo sapiens_hsa04210 0.798304893619517 0.157918396633157 0.773619234103383 -1.47289669901849 2.56273996879313
CTSF 0.175532 Apoptosis_Homo sapiens_hsa04210 0.798304893619517 0.157918396633157 0.773619234103383 -1.47289669901849 2.56273996879313
CD59 0.195646 Complement and coagulation cascades_Homo sapiens_hsa04610 0.798304893619517 0.182517856198432 0.773619234103383 -1.10674821978043 1.80559998881878
CLU 0.195646 Complement and coagulation cascades_Homo sapiens_hsa04610 0.798304893619517 0.182517856198432 0.773619234103383 -1.10674821978043 1.80559998881878
DYNC1LI1 0.212100 Phagosome_Homo sapiens_hsa04145 0.798304893619517 0.191207333435925 0.773619234103383 -1.08243607771268 1.67853259534048
TUBA1B 0.212100 Phagosome_Homo sapiens_hsa04145 0.798304893619517 0.191207333435925 0.773619234103383 -1.08243607771268 1.67853259534048
CTSL 0.212100 Phagosome_Homo sapiens_hsa04145 0.798304893619517 0.191207333435925 0.773619234103383 -1.08243607771268 1.67853259534048
GNAS 0.233394 Salivary secretion_Homo sapiens_hsa04970 0.798304893619517 0.217560559387065 0.773619234103383 -0.961253803158805 1.39865021744097
AQP5 0.233394 Salivary secretion_Homo sapiens_hsa04970 0.798304893619517 0.217560559387065 0.773619234103383 -0.961253803158805 1.39865021744097
DYNC1LI1 0.222007 Salmonella infection_Homo sapiens_hsa05132 0.798304893619517 0.20696939527716 0.773619234103383 -0.920994829718978 1.38614146595464
PFN4 0.222007 Salmonella infection_Homo sapiens_hsa05132 0.798304893619517 0.20696939527716 0.773619234103383 -0.920994829718978 1.38614146595464
TUBA1B 0.229594 Gap junction_Homo sapiens_hsa04540 0.798304893619517 0.214024075558825 0.773619234103383 -0.940419990439383 1.38377502189514
GNAS 0.229594 Gap junction_Homo sapiens_hsa04540 0.798304893619517 0.214024075558825 0.773619234103383 -0.940419990439383 1.38377502189514
GNAS 0.237198 Dilated cardiomyopathy_Homo sapiens_hsa05414 0.798304893619517 0.221102560271775 0.773619234103383 -0.958677244741393 1.37940178637801
ITGB6 0.237198 Dilated cardiomyopathy_Homo sapiens_hsa05414 0.798304893619517 0.221102560271775 0.773619234103383 -0.958677244741393 1.37940178637801
SAP18 0.241006 mRNA surveillance pathway_Homo sapiens_hsa03015 0.798304893619517 0.224649653592686 0.773619234103383 -0.83395192434915 1.18665962728984
PABPC1 0.241006 mRNA surveillance pathway_Homo sapiens_hsa03015 0.798304893619517 0.224649653592686 0.773619234103383 -0.83395192434915 1.18665962728984
H2AFJ 0.280682 Alcoholism_Homo sapiens_hsa05034 0.798304893619517 0.254378326756131 0.773619234103383 -0.900236779191472 1.1437812696895
GNAS 0.280682 Alcoholism_Homo sapiens_hsa05034 0.798304893619517 0.254378326756131 0.773619234103383 -0.900236779191472 1.1437812696895
HIST1H2AA 0.280682 Alcoholism_Homo sapiens_hsa05034 0.798304893619517 0.254378326756131 0.773619234103383 -0.900236779191472 1.1437812696895
PCYT2 0.256259 Glycerophospholipid metabolism_Homo sapiens_hsa00564 0.798304893619517 0.238880716096698 0.773619234103383 -0.765713618579468 1.04256948483577
CHPT1 0.256259 Glycerophospholipid metabolism_Homo sapiens_hsa00564 0.798304893619517 0.238880716096698 0.773619234103383 -0.765713618579468 1.04256948483577
GNAS 0.275347 Amoebiasis_Homo sapiens_hsa05146 0.798304893619517 0.256736182895793 0.773619234103383 -0.777414411981029 1.00264803375297
SERPINB6 0.275347 Amoebiasis_Homo sapiens_hsa05146 0.798304893619517 0.256736182895793 0.773619234103383 -0.777414411981029 1.00264803375297
CLTA 0.319997 Huntingtons disease_Homo sapiens_hsa05016 0.798304893619517 0.291038697085668 0.773619234103383 -0.785140449553845 0.89462241958067
COX7A2 0.319997 Huntingtons disease_Homo sapiens_hsa05016 0.798304893619517 0.291038697085668 0.773619234103383 -0.785140449553845 0.89462241958067
POLR2L 0.319997 Huntingtons disease_Homo sapiens_hsa05016 0.798304893619517 0.291038697085668 0.773619234103383 -0.785140449553845 0.89462241958067
TYMS 0.294412 Pyrimidine metabolism_Homo sapiens_hsa00240 0.798304893619517 0.274622924662829 0.773619234103383 -0.61570707648882 0.752871468405104
POLR2L 0.294412 Pyrimidine metabolism_Homo sapiens_hsa00240 0.798304893619517 0.274622924662829 0.773619234103383 -0.61570707648882 0.752871468405104
KIF5B 0.384273 Dopaminergic synapse_Homo sapiens_hsa04728 0.798304893619517 0.359698872210737 0.773619234103383 -0.452553453073017 0.432823574327084
GNAS 0.384273 Dopaminergic synapse_Homo sapiens_hsa04728 0.798304893619517 0.359698872210737 0.773619234103383 -0.452553453073017 0.432823574327084
HNRNPA3 0.402429 Spliceosome_Homo sapiens_hsa03040 0.798304893619517 0.377050833319493 0.773619234103383 -0.342286167488725 0.311561532324268
SRSF9 0.402429 Spliceosome_Homo sapiens_hsa03040 0.798304893619517 0.377050833319493 0.773619234103383 -0.342286167488725 0.311561532324268
H2AFJ 0.406030 Systemic lupus erythematosus_Homo sapiens_hsa05322 0.798304893619517 0.380499448775783 0.773619234103383 -0.198441745523345 0.178861054461018
HIST1H2AA 0.406030 Systemic lupus erythematosus_Homo sapiens_hsa05322 0.798304893619517 0.380499448775783 0.773619234103383 -0.198441745523345 0.178861054461018
CAPZA1 0.500348 Endocytosis_Homo sapiens_hsa04144 0.798304893619517 0.463657387126555 0.773619234103383 -0.19469901728741 0.134819521836986
KIF5B 0.500348 Endocytosis_Homo sapiens_hsa04144 0.798304893619517 0.463657387126555 0.773619234103383 -0.19469901728741 0.134819521836986
CLTA 0.500348 Endocytosis_Homo sapiens_hsa04144 0.798304893619517 0.463657387126555 0.773619234103383 -0.19469901728741 0.134819521836986
MPST 0.513618 Metabolic pathways_Homo sapiens_hsa01100 0.798304893619517 0.427144934458517 0.773619234103383 -0.124288595378551 0.082810374632263
TKTL2 0.513618 Metabolic pathways_Homo sapiens_hsa01100 0.798304893619517 0.427144934458517 0.773619234103383 -0.124288595378551 0.082810374632263
TKTL1 0.513618 Metabolic pathways_Homo sapiens_hsa01100 0.798304893619517 0.427144934458517 0.773619234103383 -0.124288595378551 0.082810374632263
PDXK 0.513618 Metabolic pathways_Homo sapiens_hsa01100 0.798304893619517 0.427144934458517 0.773619234103383 -0.124288595378551 0.082810374632263
PCYT2 0.513618 Metabolic pathways_Homo sapiens_hsa01100 0.798304893619517 0.427144934458517 0.773619234103383 -0.124288595378551 0.082810374632263
UAP1 0.513618 Metabolic pathways_Homo sapiens_hsa01100 0.798304893619517 0.427144934458517 0.773619234103383 -0.124288595378551 0.082810374632263
ENO1 0.513618 Metabolic pathways_Homo sapiens_hsa01100 0.798304893619517 0.427144934458517 0.773619234103383 -0.124288595378551 0.082810374632263
TYMS 0.513618 Metabolic pathways_Homo sapiens_hsa01100 0.798304893619517 0.427144934458517 0.773619234103383 -0.124288595378551 0.082810374632263
ACAT1 0.513618 Metabolic pathways_Homo sapiens_hsa01100 0.798304893619517 0.427144934458517 0.773619234103383 -0.124288595378551 0.082810374632263
SQLE 0.513618 Metabolic pathways_Homo sapiens_hsa01100 0.798304893619517 0.427144934458517 0.773619234103383 -0.124288595378551 0.082810374632263
CHPT1 0.513618 Metabolic pathways_Homo sapiens_hsa01100 0.798304893619517 0.427144934458517 0.773619234103383 -0.124288595378551 0.082810374632263
CKB 0.513618 Metabolic pathways_Homo sapiens_hsa01100 0.798304893619517 0.427144934458517 0.773619234103383 -0.124288595378551 0.082810374632263
POLR2L 0.513618 Metabolic pathways_Homo sapiens_hsa01100 0.798304893619517 0.427144934458517 0.773619234103383 -0.124288595378551 0.082810374632263
ITGB6 0.971590 PI3K-Akt signaling pathway_Homo sapiens_hsa04151 0.971590378346199 0.966093719706926 0.966093719706926 1.35528485689826 -0.039060644259254
APH1B 0.518233 Alzheimers disease_Homo sapiens_hsa05010 0.798304893619517 0.489141989042905 0.773619234103383 0.110535221074815 -0.072658246696951
COX7A2 0.518233 Alzheimers disease_Homo sapiens_hsa05010 0.798304893619517 0.489141989042905 0.773619234103383 0.110535221074815 -0.072658246696951
SRSF9 0.570326 Herpes simplex infection_Homo sapiens_hsa05168 0.798304893619517 0.540439265117329 0.773619234103383 0.296584057870604 -0.166545865821419
SKP1 0.570326 Herpes simplex infection_Homo sapiens_hsa05168 0.798304893619517 0.540439265117329 0.773619234103383 0.296584057870604 -0.166545865821419
ITGB6 0.877791 Focal adhesion_Homo sapiens_hsa04510 0.885722446827514 0.863078443045674 0.870981454464493 1.34690953154003 -0.175564846293484
CTSL 0.879063 Proteoglycans in cancer_Homo sapiens_hsa05205 0.885722446827514 0.864432721724159 0.870981454464493 1.37735566392783 -0.177539559085557
GNAS 0.873896 cAMP signaling pathway_Homo sapiens_hsa04024 0.885722446827514 0.858935121368956 0.870981454464493 1.38980729554125 -0.187337351314262
GNAS 0.846192 Calcium signaling pathway_Homo sapiens_hsa04020 0.872430150802212 0.829672228667381 0.855398499323734 1.24344262654733 -0.207666617386126
POLR2L 0.839628 Purine metabolism_Homo sapiens_hsa00230 0.872430150802212 0.822788602859231 0.855398499323734 1.20701711896806 -0.210981638012274
LYL1 0.846192 Transcriptional misregulation in cancer_Homo sapiens_hsa05202 0.872430150802212 0.829672228667381 0.855398499323734 1.26537012481209 -0.211328715898084
RAN 0.618242 Epstein-Barr virus infection_Homo sapiens_hsa05169 0.798304893619517 0.588159872565242 0.773619234103383 0.472632149579975 -0.227277124829934
POLR2L 0.618242 Epstein-Barr virus infection_Homo sapiens_hsa05169 0.798304893619517 0.588159872565242 0.773619234103383 0.472632149579975 -0.227277124829934
PTTG1 0.747099 HTLV-I infection_Homo sapiens_hsa05166 0.842177806638195 0.719478619055755 0.818438723475226 0.904716998252692 -0.263777090611152
RAN 0.747099 HTLV-I infection_Homo sapiens_hsa05166 0.842177806638195 0.719478619055755 0.818438723475226 0.904716998252692 -0.263777090611152
GNAS 0.641908 Rap1 signaling pathway_Homo sapiens_hsa04015 0.798304893619517 0.611934383564506 0.773619234103383 0.601649682104712 -0.26671749929357
PFN4 0.641908 Rap1 signaling pathway_Homo sapiens_hsa04015 0.798304893619517 0.611934383564506 0.773619234103383 0.601649682104712 -0.26671749929357
GNAS 0.806471 Oxytocin signaling pathway_Homo sapiens_hsa04921 0.851274839619252 0.788263530364995 0.832055948718606 1.29590445334338 -0.278732801218299
COX7A2 0.771317 Parkinsons disease_Homo sapiens_hsa05012 0.842177806638195 0.752063262278918 0.818438723475226 1.07789965360479 -0.279882886120782
TYMS 0.187116 One carbon pool by folate_Homo sapiens_hsa00670 0.798304893619517 0.183734544573065 0.773619234103383 0.169724304874317 -0.284462207172403
TPR 0.779097 Pathways in cancer_Homo sapiens_hsa05200 0.842177806638195 0.747801251671798 0.818438723475226 1.14681605377989 -0.286268401888914
GNAS 0.779097 Pathways in cancer_Homo sapiens_hsa05200 0.842177806638195 0.747801251671798 0.818438723475226 1.14681605377989 -0.286268401888914
CKS1B 0.779097 Pathways in cancer_Homo sapiens_hsa05200 0.842177806638195 0.747801251671798 0.818438723475226 1.14681605377989 -0.286268401888914
COX7A2 0.791807 Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 0.842482302478291 0.773116048397669 0.822595475495119 1.24016764950425 -0.289502272948968
GNAS 0.785188 Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 0.842177806638195 0.766301961275074 0.821920652012781 1.21357474631907 -0.293480817123995
RAB13 0.764051 Tight junction_Homo sapiens_hsa04530 0.842177806638195 0.744626742021214 0.818438723475226 1.11244903389292 -0.2993835404818
GNAS 0.776037 Phospholipase D signaling pathway_Homo sapiens_hsa04072 0.842177806638195 0.756901977349269 0.818438723475226 1.18719766598463 -0.301019846204601
SKP1 0.771317 Wnt signaling pathway_Homo sapiens_hsa04310 0.842177806638195 0.752063262278918 0.818438723475226 1.16782039797286 -0.303231328039004
PFN4 0.649537 Regulation of actin cytoskeleton_Homo sapiens_hsa04810 0.798304893619517 0.619628788730555 0.773619234103383 0.725452778878429 -0.313029657165777
ITGB6 0.649537 Regulation of actin cytoskeleton_Homo sapiens_hsa04810 0.798304893619517 0.619628788730555 0.773619234103383 0.725452778878429 -0.313029657165777
SKP1 0.759079 Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 0.842177806638195 0.739547412885134 0.818438723475226 1.13746789064644 -0.313541929599844
FBXO25 0.748822 FoxO signaling pathway_Homo sapiens_hsa04068 0.842177806638195 0.72908829805931 0.818438723475226 1.09637782574659 -0.317132202955503
COX7A2 0.748822 Oxidative phosphorylation_Homo sapiens_hsa00190 0.842177806638195 0.72908829805931 0.818438723475226 1.17609996860747 -0.340192190303013
GNAS 0.718317 Platelet activation_Homo sapiens_hsa04611 0.838036435312827 0.698144374590545 0.814501770355636 1.06557787000768 -0.352540450148165
GNAS 0.712387 Vascular smooth muscle contraction_Homo sapiens_hsa04270 0.838036435312827 0.69215540892774 0.814501770355636 1.16830733363534 -0.396212565192883
GNAS 0.693842 Glutamatergic synapse_Homo sapiens_hsa04724 0.82393717316543 0.673477203744841 0.799754179446998 1.10686520390455 -0.404571689866566
GNAS 0.638364 Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 0.798304893619517 0.618034641431895 0.773619234103383 0.940789599309865 -0.422270948091058
TECR 0.212002 Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 0.798304893619517 0.207107354024272 0.773619234103383 0.27280647675721 -0.423165869261595
GNAS 0.687399 Serotonergic synapse_Homo sapiens_hsa04726 0.823640686113092 0.667006380968842 0.799205843863568 1.14774164059235 -0.430219283310354
GNAS 0.642107 Estrogen signaling pathway_Homo sapiens_hsa04915 0.798304893619517 0.621756327111065 0.773619234103383 0.977720167083596 -0.433130783582398
GNAS 0.645811 Melanogenesis_Homo sapiens_hsa04916 0.798304893619517 0.625442278645519 0.773619234103383 0.998444977072885 -0.436567909682929
GNAS 0.611047 GnRH signaling pathway_Homo sapiens_hsa04912 0.798304893619517 0.59095321550045 0.773619234103383 0.887953924682012 -0.437388970541681
CHPT1 0.649478 Choline metabolism in cancer_Homo sapiens_hsa05231 0.798304893619517 0.62909283405109 0.773619234103383 1.03338901699084 -0.445996830412239
ENO1 0.656698 HIF-1 signaling pathway_Homo sapiens_hsa04066 0.798304893619517 0.636289092898725 0.773619234103383 1.06218272666537 -0.446681038838476
GNAS 0.626899 Circadian entrainment_Homo sapiens_hsa04713 0.798304893619517 0.606651751267818 0.773619234103383 0.964504852931025 -0.450395351184399
GNAS 0.568426 Aldosterone synthesis and secretion_Homo sapiens_hsa04925 0.798304893619517 0.548955236922523 0.773619234103383 0.798320152379643 -0.450958019810946
GNAS 0.649478 Glucagon signaling pathway_Homo sapiens_hsa04922 0.798304893619517 0.62909283405109 0.773619234103383 1.05274393932387 -0.454350155124887
SKP1 0.581679 TGF-beta signaling pathway_Homo sapiens_hsa04350 0.798304893619517 0.561981906060616 0.773619234103383 0.852625685507733 -0.461984060662789
GNAS 0.611047 Morphine addiction_Homo sapiens_hsa05032 0.798304893619517 0.59095321550045 0.773619234103383 0.951051629421494 -0.46846968244847
GNAS 0.660252 Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 0.798304893619517 0.639835456777234 0.773619234103383 1.13114064100174 -0.469574310770617
GNAS 0.500842 Amphetamine addiction_Homo sapiens_hsa05031 0.798304893619517 0.48293795267898 0.773619234103383 0.682596512910326 -0.471991938504632
CTSL 0.606981 Rheumatoid arthritis_Homo sapiens_hsa05323 0.798304893619517 0.586933099685242 0.773619234103383 0.945655820560582 -0.472125988044855
GNAS 0.630760 Pancreatic secretion_Homo sapiens_hsa04972 0.798304893619517 0.61048269954951 0.773619234103383 1.02908074486092 -0.474231365136394
GNAS 0.463199 Long-term depression_Homo sapiens_hsa04730 0.798304893619517 0.446446575434215 0.773619234103383 0.620078353655238 -0.477211542293603
CD59 0.598721 Hematopoietic cell lineage_Homo sapiens_hsa04640 0.798304893619517 0.578775727618377 0.773619234103383 0.931995564773968 -0.47807621101689
GNAS 0.440434 Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 0.798304893619517 0.424467109878225 0.773619234103383 0.59966477226574 -0.491721822221533
GNAS 0.586006 Insulin secretion_Homo sapiens_hsa04911 0.798304893619517 0.566241198262869 0.773619234103383 0.921839587510084 -0.492654880331079
CLTA 0.554756 Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 0.798304893619517 0.535547018078605 0.773619234103383 0.840473681139328 -0.495229689667916
RAN 0.602872 Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 0.798304893619517 0.582874060790748 0.773619234103383 0.981176859886368 -0.496524380255853
GNAS 0.535856 Gastric acid secretion_Homo sapiens_hsa04971 0.798304893619517 0.517056807169059 0.773619234103383 0.799368882830641 -0.498717390333991
GNAS 0.485042 Renin secretion_Homo sapiens_hsa04924 0.798304893619517 0.467598528205533 0.773619234103383 0.712001072792277 -0.515147080520542
CKS1B 0.590288 Small cell lung cancer_Homo sapiens_hsa05222 0.798304893619517 0.570459676312272 0.773619234103383 0.980052858447494 -0.516629685000449
ITGB6 0.572890 ECM-receptor interaction_Homo sapiens_hsa04512 0.798304893619517 0.553339319800549 0.773619234103383 0.961097090026456 -0.535390988825523
CTSL 0.550104 Antigen processing and presentation_Homo sapiens_hsa04612 0.798304893619517 0.530990929970032 0.773619234103383 0.922680819203744 -0.551437990717626
FABP5 0.511106 PPAR signaling pathway_Homo sapiens_hsa03320 0.798304893619517 0.492921452968767 0.773619234103383 0.827631734414553 -0.555488894350333
COX7A2 0.554756 Cardiac muscle contraction_Homo sapiens_hsa04260 0.798304893619517 0.535547018078605 0.773619234103383 0.943122039281401 -0.55571286206031
TPR 0.259523 Thyroid cancer_Homo sapiens_hsa05216 0.798304893619517 0.251892253569254 0.773619234103383 0.423423141304928 -0.571160035006679
PIN1 0.516159 RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 0.798304893619517 0.497841735674114 0.773619234103383 0.874076972628553 -0.578062835084158
POLR2L 0.485042 Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 0.798304893619517 0.467598528205533 0.773619234103383 0.805131961122759 -0.582529149260387
GNAS 0.521160 Bile secretion_Homo sapiens_hsa04976 0.798304893619517 0.50271497128709 0.773619234103383 0.894022507225692 -0.582633132613607
ITGB6 0.577307 Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 0.798304893619517 0.557681410778926 0.773619234103383 1.06343758660477 -0.584232684869698
PFN4 0.490363 Shigellosis_Homo sapiens_hsa05131 0.798304893619517 0.472760841063753 0.773619234103383 0.823152819182456 -0.586586471548578
ENO1 0.500842 Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 0.798304893619517 0.48293795267898 0.773619234103383 0.853309989693165 -0.590034417936669
GNAS 0.521160 Thyroid hormone synthesis_Homo sapiens_hsa04918 0.798304893619517 0.50271497128709 0.773619234103383 0.926058111127533 -0.603510687826864
ITGB6 0.535856 Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 0.798304893619517 0.517056807169059 0.773619234103383 0.977472681767377 -0.609834377399796
TECR 0.228170 Fatty acid elongation_Homo sapiens_hsa00062 0.798304893619517 0.222321589628825 0.773619234103383 0.426375727567001 -0.630039363642154
TAF9 0.372756 Basal transcription factors_Homo sapiens_hsa03022 0.798304893619517 0.359492168309341 0.773619234103383 0.658969017957113 -0.650291416677059
CLTA 0.479665 Synaptic vesicle cycle_Homo sapiens_hsa04721 0.798304893619517 0.462386420507893 0.773619234103383 0.889171002937837 -0.653244010913165
SQLE 0.187116 Steroid biosynthesis_Homo sapiens_hsa00100 0.798304893619517 0.183734544573065 0.773619234103383 0.396381866122866 -0.664345985119358
KRT10 0.440434 Staphylococcus aureus infection_Homo sapiens_hsa05150 0.798304893619517 0.424467109878225 0.773619234103383 0.841804234636756 -0.690274852473667
TUBA1B 0.434594 Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 0.798304893619517 0.418839235770764 0.773619234103383 0.828397608034614 -0.690338725310846
UAP1 0.391983 Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 0.798304893619517 0.377896942344536 0.773619234103383 0.744916492803461 -0.697642586849357
APH1B 0.391983 Notch signaling pathway_Homo sapiens_hsa04330 0.798304893619517 0.377896942344536 0.773619234103383 0.763915511892686 -0.715435889794126
ABCA5 0.366213 ABC transporters_Homo sapiens_hsa02010 0.798304893619517 0.353238825513031 0.773619234103383 0.732011598777962 -0.735334067318606
GNAS 0.398260 Cocaine addiction_Homo sapiens_hsa05030 0.798304893619517 0.383915296009942 0.773619234103383 0.799462968038807 -0.736025382719568
ACAT1 0.416709 Lysine degradation_Homo sapiens_hsa00310 0.798304893619517 0.401628259096028 0.773619234103383 0.855718119935091 -0.749068072390946
GNAS 0.404473 Ovarian steroidogenesis_Homo sapiens_hsa04913 0.798304893619517 0.389876274929646 0.773619234103383 0.836931702844785 -0.757565034256193
ACAT1 0.391983 Valine leucine and isoleucine degradation_Homo sapiens_hsa00280 0.798304893619517 0.377896942344536 0.773619234103383 0.816380108688301 -0.764570977257089
CKB 0.404473 Arginine and proline metabolism_Homo sapiens_hsa00330 0.798304893619517 0.389876274929646 0.773619234103383 0.859640754866333 -0.778120575065739
SSBP1 0.212002 Mismatch repair_Homo sapiens_hsa03430 0.798304893619517 0.207107354024272 0.773619234103383 0.50199790478373 -0.778677919492217
ACAT1 0.366213 Fatty acid degradation_Homo sapiens_hsa00071 0.798304893619517 0.353238825513031 0.773619234103383 0.781790733643012 -0.785339140693163
CHPT1 0.372756 Ether lipid metabolism_Homo sapiens_hsa00565 0.798304893619517 0.359492168309341 0.773619234103383 0.831116132929438 -0.820171620786301
MPST 0.372756 Cysteine and methionine metabolism_Homo sapiens_hsa00270 0.798304893619517 0.359492168309341 0.773619234103383 0.837961088493641 -0.826926438887972
ACAT1 0.339358 Tryptophan metabolism_Homo sapiens_hsa00380 0.798304893619517 0.327618274400508 0.773619234103383 0.78336293188172 -0.846580509841721
ACAT1 0.203792 Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 0.798304893619517 0.199390637274809 0.773619234103383 0.564488511246042 -0.89790552661986
ACAT1 0.251806 Butanoate metabolism_Homo sapiens_hsa00650 0.798304893619517 0.244605141875052 0.773619234103383 0.658502637738195 -0.908139667596044
ATG3 0.332469 Regulation of autophagy_Homo sapiens_hsa04140 0.798304893619517 0.321058452683033 0.773619234103383 0.865736947328453 -0.953357528056197
ACAT1 0.339358 Pyruvate metabolism_Homo sapiens_hsa00620 0.798304893619517 0.327618274400508 0.773619234103383 0.882544447471071 -0.953765997713625
ACAT1 0.251806 Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 0.798304893619517 0.244605141875052 0.773619234103383 0.718798467745404 -0.991293525883161
SSBP1 0.311370 DNA replication_Homo sapiens_hsa03030 0.798304893619517 0.300998306236596 0.773619234103383 0.897452050240525 -1.04712336621163
ACAT1 0.282202 Propanoate metabolism_Homo sapiens_hsa00640 0.798304893619517 0.273340539509384 0.773619234103383 0.865031801362053 -1.09437850808133
SSBP1 0.259523 Homologous recombination_Homo sapiens_hsa03440 0.798304893619517 0.251892253569254 0.773619234103383 0.879441176232804 -1.18628767302472
SKP1 0.267161 Circadian rhythm_Homo sapiens_hsa04710 0.798304893619517 0.259110092214105 0.773619234103383 1.01703907293145 -1.34239459038682
POLR2L 0.282202 RNA polymerase_Homo sapiens_hsa03020 0.798304893619517 0.273340539509384 0.773619234103383 1.09285930556286 -1.38261013581409
PDXK 0.060238 Vitamin B6 metabolism_Homo sapiens_hsa00750 0.769646451429668 0.065370013554347 0.773619234103383 0.552711724419846 -1.55282000273016
MPST 0.098376 Sulfur metabolism_Homo sapiens_hsa00920 0.769646451429668 0.100814515234088 0.773619234103383 0.946699722494259 -2.19535860645414
MPST 0.098376 Sulfur relay system_Homo sapiens_hsa04122 0.769646451429668 0.100814515234088 0.773619234103383 1.00196956511183 -2.32352715006392
ACAT1 0.098376 Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 0.769646451429668 0.100814515234088 0.773619234103383 1.10422355872417 -2.56065005143088

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