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Table S1: 149 transcripts representing statistically significant (P<0.05) differences in testicular expression between three NOA subclasses

OKADA, Hiroyuki, et al. Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility. PLoS genetics, 2008, 4. Jg., Nr. 2, S. e26.

Publication: https://doi.org/10.1371/journal.pgen.0040026

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The publication Genome-Wide Expression of Azoospermia Testes Demonstrates a Specific Profile and Implicates ART3 in Genetic Susceptibility by Hiroyuki Okada and Atsushi Tajima and Kazuyoshi Shichiri and Atsushi Tanaka and Kenichi Tanaka and Ituro Inoue is published under an open access no derivatives license: : https://creativecommons.org/. Open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Table

CHR GENE Name GeneAc.No. ProbeId Expression PostHocSignificance GeneClass
6q25.3 ACAT2 acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) NM_005891 A_23_P383835 OA<NOA 1 vs. 2
13q12-13 ATP8A2 ATPase; aminophospholipid transporter-like; Class I; type 8A; member 2 NM_016529 A_23_P258612 NOA<OA 1 vs. 2
20p11.1 GGTLA4 gamma-glutamyltransferase-like activity 4 NM_080920 A_23_P57199 NOA<OA 1 vs. 2
10q23-q24 PAPSS2 3-phosphoadenosine 5-phosphosulfate synthase 2 NM_004670 A_23_P104492 OA<NOA 1 vs. 2
1p36.1-p35 STMN1 stathmin 1/oncoprotein 18 NM_005563 A_23_P200866 NOA<OA 1 vs. 2
6p21.3 BTNL2 butyrophilin-like 2 (MHC class II associated) NM_019602 A_23_P376686 OA<NOA 1 vs. 3
12q23-q24.1 EID3 E1A-like inhibitor of differentiation 3 AK098698 A_23_P65068 NOA<OA 1 vs. 3
5q14 GLRX glutaredoxin (thioltransferase) NM_002064 A_23_P69908 OA<NOA 1 vs. 3
1p13.1 HSD3B1 hydroxy-delta-5-steroid dehydrogenase; 3 beta- and steroid delta-isomerase 1 NM_000862 A_23_P97173 OA<NOA 1 vs. 3
1p13.1 HSD3B2 hydroxy-delta-5-steroid dehydrogenase; 3 beta- and steroid delta-isomerase 2 NM_000198 A_23_P51576 OA<NOA 1 vs. 3
19p12 PBX4 pre-B-cell leukemia transcription factor 4 NM_025245 A_23_P90419 NOA<OA 1 vs. 3
Xq24 PEPP-2 PEPP subfamily gene 2 NM_032498 A_23_P352494 NOA<OA 1 vs. 3
14q23.3 PLEK2 pleckstrin 2 NM_016445 A_23_P151506 OA<NOA 1 vs. 3
8p12-p11.1 SFRP1 secreted frizzled-related protein 1 BC036503 A_23_P10121 OA<NOA 1 vs. 3
2q32 SLC40A1 solute carrier family 40 (iron-regulated transporter); member 1 NM_014585 A_23_P102391 OA<NOA 1 vs. 3
19q13.1 SPINT2 serine protease inhibitor; Kunitz type; 2 NM_021102 A_23_P27795 NOA<OA 1 vs. 3
20p11.23-p11.22 VSX1 visual system homeobox 1 homolog; CHX10-like (zebrafish) NM_014588 A_23_P131990 OA<NOA 1 vs. 3
16q22.2 CALB2 calbindin 2; 29kDa (calretinin) NM_001740 A_23_P21092 OA<NOA (1 vs. 2) & (1 vs. 3)
8p21.3 ChGn chondroitin beta1;4 N-acetylgalactosaminyltransferase NM_018371 A_23_P134835 OA<NOA (1 vs. 2) & (1 vs. 3)
Xp11.23 CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 NM_019886 A_23_P319617 OA<NOA (1 vs. 2) & (1 vs. 3)
11q12.2 CYBASC3 cytochrome b; ascorbate dependent 3 THC1943229 A_23_P127771 OA<NOA (1 vs. 2) & (1 vs. 3)
9p24.3 DMRT1 doublesex and mab-3 related transcription factor 1 NM_021951 A_23_P169293 NOA<OA (1 vs. 2) & (1 vs. 3) Male infertility
10q24-qter GRK5 G protein-coupled receptor kinase 5 NM_005308 A_23_P12884 OA<NOA (1 vs. 2) & (1 vs. 3)
1q21.2 HIST2H2AA histone 2; H2aa NM_003516 A_23_P103981 NOA<OA (1 vs. 2) & (1 vs. 3)
2q33-q36 IGFBP5 insulin-like growth factor binding protein 5 NM_000599 A_23_P154115 OA<NOA (1 vs. 2) & (1 vs. 3)
2q24.1 LOC92196 similar to death-associated protein ENST00000309950 A_23_P165598 OA<NOA (1 vs. 2) & (1 vs. 3)
Xp22.12 MAP3K15 mitogen-activated protein kinase kinase kinase 15 AK122632 A_23_P158919 OA<NOA (1 vs. 2) & (1 vs. 3)
16q13 MT1E metallothionein 1E (functional) NM_175617 A_23_P206724 OA<NOA (1 vs. 2) & (1 vs. 3)
16q13 MT1G metallothionein 1G NM_005950 A_23_P206701 OA<NOA (1 vs. 2) & (1 vs. 3)
6q22.33 RSPO3 R-spondin 3 homolog (Xenopus laevis) NM_032784 A_23_P111402 OA<NOA (1 vs. 2) & (1 vs. 3)
4q32-q34 SC4MOL sterol-C4-methyl oxidase-like NM_006745 A_23_P110184 OA<NOA (1 vs. 2) & (1 vs. 3)
10q21.2 SLC16A9 solute carrier family 16 (monocarboxylic acid transporters); member 9 NM_194298 A_23_P115726 OA<NOA (1 vs. 2) & (1 vs. 3)
1q21-q22 SPRR2F small proline-rich protein 2F THC1856852 A_23_P137478 OA<NOA (1 vs. 2) & (1 vs. 3)
6q22-q23 TPD52L1 tumor protein D52-like 1 NM_003287 A_23_P31143 OA<NOA (1 vs. 2) & (1 vs. 3)
1p31 AK5 adenylate kinase 5 NM_174858 A_23_P200015 NOA<OA 2 vs. 3
21q11.2 ANKRD21 ankyrin repeat domain 21 NM_174981 A_23_P420348 NOA<OA 2 vs. 3
4q13-q21 AREG amphiregulin (schwannoma-derived growth factor) NM_001657 A_23_P259071 NOA<OA 2 vs. 3
17q25 BIRC5 baculoviral IAP repeat-containing 5 (survivin) NM_001168 A_23_P118815 NOA<OA 2 vs. 3
17q21 BRCA1 breast cancer 1; early onset NM_007294 A_23_P207400 NOA<OA 2 vs. 3
18q21.1 CCDC11 coiled-coil domain containing 11 NM_145020 A_23_P384532 NOA<OA 2 vs. 3
15q22.2 CCNB2 cyclin B2 NM_004701 A_23_P65757 NOA<OA 2 vs. 3
Xp11 CCNB3 cyclin B3 NM_033031 A_23_P171107 NOA<OA 2 vs. 3
9q22 CKS2 CDC28 protein kinase regulatory subunit 2 NM_001827 A_23_P71727 NOA<OA 2 vs. 3 Male infertility
Xq28 CSAG2 CSAG family; member 2 NM_004909 A_23_P159637 NOA<OA 2 vs. 3 CT antigens
16q23.3 DNCL2B dynein; cytoplasmic; light polypeptide 2B NM_130897 A_23_P94840 NOA<OA 2 vs. 3
10q25 DUSP5 dual specificity phosphatase 5 NM_004419 A_23_P150016 NOA<OA 2 vs. 3
10q22.3 DYDC1 DPY30 domain containing 1 NM_138812 A_23_P360990 NOA<OA 2 vs. 3
7q35-q36 EZH2 enhancer of zeste homolog 2 (Drosophila) NM_004456 A_23_P259641 NOA<OA 2 vs. 3
6q23.2 FAM54A family with sequence similarity 54; member A NM_138419 A_23_P253752 NOA<OA 2 vs. 3
16q24.3 FANCA Fanconi anemia; complementation group A NM_000135 A_23_P206441 NOA<OA 2 vs. 3 Male infertility
18q22.3 FBXO15 F-box protein 15 NM_152676 A_23_P342709 NOA<OA 2 vs. 3
6p22-p21.3 HIST1H2AL histone 1; H2al NM_003511 A_23_P258477 NOA<OA 2 vs. 3
Xq13.1-q28 IL13RA2 interleukin 13 receptor; alpha 2 NM_000640 A_23_P85215 NOA<OA 2 vs. 3
12q13.3 IL23A interleukin 23; alpha subunit p19 NM_016584 A_23_P76078 NOA<OA 2 vs. 3
16q24.1 LOC161931 testis nuclear RNA-binding protein-like NM_139174 A_23_P49136 NOA<OA 2 vs. 3
Xq28 MAGEA4 melanoma antigen; family A; 4 NM_002362 A_23_P171175 NOA<OA 2 vs. 3 CT antigens
Xq27 MAGEC2 melanoma antigen; family C; 2 NM_016249 A_23_P62099 NOA<OA 2 vs. 3 CT antigens
1p33-p32.2 MYCBP c-myc binding protein NM_012333 A_23_P201655 NOA<OA 2 vs. 3
10q26 NKX6-2 NK6 transcription factor related; locus 2 (Drosophila) NM_177400 A_23_P86587 NOA<OA 2 vs. 3
4q31.22 NYD-SP14 NYD-SP14 protein NM_031956 A_23_P92517 NOA<OA 2 vs. 3
15q15.1 OIP5 Opa-interacting protein 5 NM_007280 A_23_P379614 NOA<OA 2 vs. 3
11q13 OVOL1 ovo-like 1(Drosophila) NM_004561 A_23_P202810 NOA<OA 2 vs. 3 Male subfertility
1p34.1 PIK3R3 phosphoinositide-3-kinase; regulatory subunit; polypeptide 3 (p55; gamma) NM_003629 A_23_P22970 NOA<OA 2 vs. 3
11q21 PIWIL4 piwi-like 4 (Drosophila) NM_152431 A_23_P427760 NOA<OA 2 vs. 3
Xp11.4-Xp11.3 PPP1R2P9 protein phosphatase 1; regulatory (inhibitor) subunit 2 pseudogene 9 NM_025210 A_23_P34007 NOA<OA 2 vs. 3
12q24.11 RAD9B RAD9 homolog B (S. cerevisiae) NM_152442 A_23_P333650 NOA<OA 2 vs. 3
22q13.31 RIBC2 RIB43A domain with coiled-coils 2 NM_015653 A_23_P166526 NOA<OA 2 vs. 3
4q28.1 SLC25A31 solute carrier family 25 (mitochondrial carrier;adenine nucleotide translocator); member 31 NM_031291 A_23_P18755 NOA<OA 2 vs. 3
11q24.2 SPA17 sperm autoantigenic protein 17 NM_017425 A_23_P104876 NOA<OA 2 vs. 3 CT antigens
Xq27.1 SPANXA1 sperm protein associated with the nucleus; X-linked; family member A1 NM_013453 A_23_P96300 NOA<OA 2 vs. 3 CT antigens
4q34.2 SPATA4 spermatogenesis associated 4 NM_144644 A_23_P393025 NOA<OA 2 vs. 3
6q15 SRrp35 serine-arginine repressor protein (35 kDa) NM_080743 A_23_P110901 NOA<OA 2 vs. 3
4p16.3 TACC3 transforming; acidic coiled-coil containing protein 3 NM_006342 A_23_P212844 NOA<OA 2 vs. 3
19q13.4 TNNT1 troponin T1; skeletal; slow BC022086 A_23_P56050 NOA<OA 2 vs. 3
17q21-q22 TOP2A topoisomerase (DNA) II alpha 170kDa NM_001067 A_23_P118834 NOA<OA 2 vs. 3
13q12.11 TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 A_23_P219230 A_23_P219230 NOA<OA 2 vs. 3
5q22.3 TRIM36 tripartite motif-containing 36 NM_018700 A_23_P110569 NOA<OA 2 vs. 3
18p11.32 TYMS thymidylate synthetase NM_001071 A_23_P50096 NOA<OA 2 vs. 3
19p13.3 UHRF1 ubiquitin-like; containing PHD and RING finger domains; 1 NM_013282 A_23_P208880 NOA<OA 2 vs. 3
5p15.2-p13.1 UNG2 uracil-DNA glycosylase 2 NM_021147 A_23_P92860 NOA<OA 2 vs. 3
7q22.1 ZCWPW1 zinc finger; CW-type with PWWP domain 1 NM_017984 A_23_P70897 NOA<OA 2 vs. 3
19q13.32 ZNF541 zinc finger protein 541 NM_032255 A_23_P50517 NOA<OA 2 vs. 3
7q31 ANKRD7 ankyrin repeat domain 7 NM_019644 A_23_P250231 NOA<OA (1 vs. 3) & (2 vs. 3)
4q21.1 ART3 ADP-ribosyltransferase 3 NM_001179 A_23_P80918 NOA<OA (1 vs. 3) & (2 vs. 3)
2q14 BUB1 BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) NM_004336 A_23_P124417 NOA<OA (1 vs. 3) & (2 vs. 3)
22q11.21 CDC45L CDC45 cell division cycle 45-like (S. cerevisiae) NM_003504 A_23_P57379 NOA<OA (1 vs. 3) & (2 vs. 3)
8p21.2 CDCA2 cell division cycle associated 2 NM_152562 A_23_P385861 NOA<OA (1 vs. 3) & (2 vs. 3)
11q12.1 CDCA5 cell division cycle associated 5 NM_080668 A_23_P104651 NOA<OA (1 vs. 3) & (2 vs. 3)
16q24.3 CDT1 DNA replication factor NM_030928 A_23_P37704 NOA<OA (1 vs. 3) & (2 vs. 3)
Xq26.3 CT45-2 cancer/testis antigen CT45-2 NM_152582 A_23_P362076 NOA<OA (1 vs. 3) & (2 vs. 3) CT antigens
Xq28 CTAG1B cancer/testis antigen 1B NM_001327 A_23_P148541 NOA<OA (1 vs. 3) & (2 vs. 3) CT antigens
3p24.3 DAZL deleted in azoospermia-like NM_001351 A_23_P212105 NOA<OA (1 vs. 3) & (2 vs. 3) Male infertility
5q11.2 DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 NM_019039 A_23_P256624 NOA<OA (1 vs. 3) & (2 vs. 3) Male infertility
6q12-q13 DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 NM_018665 A_23_P156445 NOA<OA (1 vs. 3) & (2 vs. 3)
1p32.3 DMRTB1 DMRT-like family B with proline-rich C-terminal; 1 NM_033067 A_23_P417821 NOA<OA (1 vs. 3) & (2 vs. 3)
19q13.2 DMRTC2 DMRT-like family C2 NM_033052 A_23_P300245 NOA<OA (1 vs. 3) & (2 vs. 3)
21q22.2 DSCR8 Down syndrome critical region gene 8 NM_032589 A_23_P6252 NOA<OA (1 vs. 3) & (2 vs. 3) CT antigens
2p13 EGR4 early growth response 4 NM_001965 A_23_P380318 NOA<OA (1 vs. 3) & (2 vs. 3) Male infertility
4p16.3 FGFR3 fibroblast growth factor receptor 3 (achondroplasia; thanatophoric dwarfism) NM_000142 A_23_P500501 NOA<OA (1 vs. 3) & (2 vs. 3)
7q11.23 FKBP6 FK506 binding protein 6; 36kDa NM_003602 A_23_P250874 NOA<OA (1 vs. 3) & (2 vs. 3) Male infertility
Xq27.3-q28 FMR1NB fragile X mental retardation 1 neighbor NM_152578 A_23_P396112 NOA<OA (1 vs. 3) & (2 vs. 3) CT antigens
Xp11.4-p11.2 GAGE4 G antigen 4 NM_001474 A_23_P217196 NOA<OA (1 vs. 3) & (2 vs. 3) CT antigens
4q31.3 GAJ GAJ protein NM_032117 A_23_P133123 NOA<OA (1 vs. 3) & (2 vs. 3)
6p22.2 HIST1H2AA histone 1; H2aa NM_170745 A_23_P355439 NOA<OA (1 vs. 3) & (2 vs. 3)
6p22.2 HIST1H2BA histone 1; H2ba NM_170610 A_23_P323821 NOA<OA (1 vs. 3) & (2 vs. 3)
11p15 HNRNPG-T testes-specific heterogenous nuclear ribonucleoprotein G-T NM_014469 A_23_P61967 NOA<OA (1 vs. 3) & (2 vs. 3)
1q21.2 HORMAD1 HORMA domain containing protein NM_032132 A_23_P327530 NOA<OA (1 vs. 3) & (2 vs. 3)
2q14.2 INHBB inhibin; beta B (activin AB beta polypeptide) NM_002193 A_23_P153964 NOA<OA (1 vs. 3) & (2 vs. 3)
13q33.1 LOC93081 hypothetical protein BC015148 NM_138779 A_23_P362046 NOA<OA (1 vs. 3) & (2 vs. 3)
2q21.1 LOC112714 similar to alpha tubulin NM_207312 A_23_P56736 NOA<OA (1 vs. 3) & (2 vs. 3)
Xq27.3 LOC158812 hypothetical LOC158812 XM_088679 A_23_P255457 NOA<OA (1 vs. 3) & (2 vs. 3)
Xq24 LOC255313 hypothetical protein LOC255313 NM_173571 A_23_P305074 NOA<OA (1 vs. 3) & (2 vs. 3)
3p22.1 LOC339903 hypothetical protein LOC339903 BC041820 A_23_P80551 NOA<OA (1 vs. 3) & (2 vs. 3)
Xq28 MAGEA2 melanoma antigen; family A; 2 NM_005361 A_23_P148255 NOA<OA (1 vs. 3) & (2 vs. 3) CT antigens
Xq28 MAGEA9 melanoma antigen; family A; 9 NM_005365 A_23_P85094 NOA<OA (1 vs. 3) & (2 vs. 3) CT antigens
16p13.3 MGC35212 hypothetical protein MGC35212 NM_152764 A_23_P398545 NOA<OA (1 vs. 3) & (2 vs. 3)
22q13.2 MGC40042 similar to mouse meiosis defective 1 gene AK093341 A_23_P211561 NOA<OA (1 vs. 3) & (2 vs. 3)
11q13.2-q13.3 MTL5 metallothionein-like 5; testis-specific (tesmin) NM_004923 A_23_P161507 NOA<OA (1 vs. 3) & (2 vs. 3)
15q21.1 NMES1 normal mucosa of esophagus specific 1 NM_032413 A_23_P26024 NOA<OA (1 vs. 3) & (2 vs. 3)
17p13.3 NYD-SP20 testes development-related NYD-SP20 NM_032598 A_23_P101084 NOA<OA (1 vs. 3) & (2 vs. 3)
Xq24 OTEX paired-like homeobox protein OTEX NM_139282 A_23_P85083 NOA<OA (1 vs. 3) & (2 vs. 3)
Xp11.23 PAGE1 P antigen family; member 1 (prostate associated) NM_003785 A_23_P171104 NOA<OA (1 vs. 3) & (2 vs. 3) CT antigens
Xp11.21 PAGE5 P antigen family; member 5 NM_130467 A_23_P22744 NOA<OA (1 vs. 3) & (2 vs. 3) CT antigens
Xq28 PASD1 PAS domain containing 1 NM_173493 A_23_P404057 NOA<OA (1 vs. 3) & (2 vs. 3)
Xq24 PEPP-2 PEPP subfamily gene 2 AL590524 A_23_P73677 NOA<OA (1 vs. 3) & (2 vs. 3)
12q13.12 RACGAP1 Rac GTPase activating protein 1 NM_013277 A_23_P65110 NOA<OA (1 vs. 3) & (2 vs. 3)
1p32 RAD54L RAD54-like (S. cerevisiae) NM_003579 A_23_P74115 NOA<OA (1 vs. 3) & (2 vs. 3)
8q24.3 RECQL4 RecQ protein-like 4 NM_004260 A_23_P71558 NOA<OA (1 vs. 3) & (2 vs. 3)
17q11.2 SPAG5 sperm associated antigen 5 NM_006461 A_23_P89509 NOA<OA (1 vs. 3) & (2 vs. 3)
4q12 SPINK2 serine protease inhibitor; Kazal type 2 (acrosin-trypsin inhibitor) NM_021114 A_23_P155688 NOA<OA (1 vs. 3) & (2 vs. 3)
Xp11.23 SSX3 synovial sarcoma; X breakpoint 3 NM_021014 A_23_P252025 NOA<OA (1 vs. 3) & (2 vs. 3) CT antigens
Xp11.2 SSX6 synovial sarcoma; X breakpoint 6 NM_173357 A_23_P33881 NOA<OA (1 vs. 3) & (2 vs. 3)
7q22.1 STAG3 stromal antigen 3 NM_012447 A_23_P145657 NOA<OA (1 vs. 3) & (2 vs. 3)
12q23.2 SYCP3 synaptonemal complex protein 3 NM_153694 A_23_P76374 NOA<OA (1 vs. 3) & (2 vs. 3) Male infertility
17q22 TEX14 testis expressed sequence 14 NM_031272 A_23_P54996 NOA<OA (1 vs. 3) & (2 vs. 3) Male infertility
19q13.31 TEX101 testis expressed sequence 101 NM_031451 A_23_P130906 NOA<OA (1 vs. 3) & (2 vs. 3)
Xq28 TKTL1 transketolase-like 1 NM_012253 A_23_P259901 NOA<OA (1 vs. 3) & (2 vs. 3)
21p11 TPTE transmembrane phosphatase with tensin homology A_23_P88012 A_23_P88012 NOA<OA (1 vs. 3) & (2 vs. 3) CT antigens
21p11 TPTE transmembrane phosphatase with tensin homology NM_013315 A_23_P345746 NOA<OA (1 vs. 3) & (2 vs. 3) CT antigens
Yp11.2 TSPY1 testis specific protein; Y-linked 1 NM_003308 A_23_P22800 NOA<OA (1 vs. 3) & (2 vs. 3)
Yp11.2 TSPY2 testis specific protein; Y-linked 2 NM_022573 A_23_P251391 NOA<OA (1 vs. 3) & (2 vs. 3)
Yp11.2 TSPY2 testis specific protein; Y-linked 2 NM_022573 A_23_P34200 NOA<OA (1 vs. 3) & (2 vs. 3)
Xp22 VCX variable charge; X-linked NM_013452 A_23_P252572 NOA<OA (1 vs. 3) & (2 vs. 3)
Xp22.32 VCX2 variable charge; X-linked 2 NM_016378 A_23_P114243 NOA<OA (1 vs. 3) & (2 vs. 3)
Xp22 VCX3A variable charge; X-linked 3 NM_016379 A_23_P171188 NOA<OA (1 vs. 3) & (2 vs. 3)
Yq11.221 VCY variable charge; Y-linked NM_004679 A_23_P11390 NOA<OA (1 vs. 3) & (2 vs. 3)
Xp11.22-p11.21 XAGE3 X antigen family; member 3 NM_130776 A_23_P114343 NOA<OA (1 vs. 3) & (2 vs. 3) CT antigens
Xp11.22 XAGE5 X antigen family; member 5 NM_130775 A_23_P301497 NOA<OA (1 vs. 3) & (2 vs. 3) CT antigens
Xp11.22-p11.21 XAGE1 X antigen family; member 1 NM_133431 A_23_P383310 NOA<OA all comparisons CT antigens

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