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A novel cross-species inhibitor to study the function of CatSper Ca 2+ channels in sperm

A. Rennhack, Schiffer C, Brenker C, Fridman D, Nitao ET, Cheng YM, Tamburrino L, Balbach M, Stölting G, Berger TK, Kierzek M, Alvarez L, Wachten D, Zeng XH, Baldi E, Publicover SJ, Kaupp UB, Strünker T., 03.05.2018

RENNHACK, Andreas, et al. A novel cross‐species inhibitor to study the function of CatSper Ca2+ channels in sperm. British journal of pharmacology, 2018, 175. Jg., Nr. 15, S. 3144-3161.

Publication: https://doi.org/10.1111/bph.14355

Disclaimer

The publication A novel cross-species inhibitor to study the function of CatSper Ca 2+ channels in sperm by A. Rennhack, Schiffer C, Brenker C, Fridman D, Nitao ET, Cheng YM, Tamburrino L, Balbach M, Stölting G, Berger TK, Kierzek M, Alvarez L, Wachten D, Zeng XH, Baldi E, Publicover SJ, Kaupp UB, Strünker T. is not published under an open access license. Therefore, only content curated by the MFGA team can be shown. For abstract, images and tables please follow the link to the original publication.

Curation by the MFGA team
Relevant data sets presented in the publication have been identified. If possible, annotations (title, general information, conditions, processed tissue types and processed cell types) have been added based on information from the publication.

Data set 1: Synthesis of RU1968

Other: Functional Study

Species

Species
Human

Conditions

Human phenotype ontology Participants Comment
HP:other: Other

Cell Types

Cell ontology Maturity Description Species Replicates Cells per replicate
CL_0000019: sperm Human

Data set 2: RU1968F1 is a potent cross‐species inhibitor of CatSper channels

Other: Functional Study

Species

Species
Human
Sea Urchin
Mouse

Cell Types

Cell ontology Maturity Description Species Replicates Cells per replicate
CL_0000019: sperm Human Fig 3.
Mouse Fig 4.
Sea urchin Fig 5.
Human and mouse Fig 6.
Sperm cells of human, mouse and sea urchin

Data set 3: RU1968F1 inhibits human but not mouse Slo3 channels

Other: Functional Study

Species

Species
Human
Mouse

Cell Types

Cell ontology Maturity Description Species Replicates Cells per replicate
CL_0000019: sperm from human and mouse

Data set 4: RU19681F1 suppresses progesterone‐evoked motility responses in human sperm

Other: Functional Study

Species

Species
Human

Cell Types

Cell ontology Maturity Description Species Replicates Cells per replicate
CL_0000019: sperm Human