Ageing in men with normal spermatogenesis alters spermatogonial dynamics and nuclear morphology in Sertoli cells
E. Pohl, V. Höffken, S. Schlatt, S. Kliesch, J. Gromoll, J. Wistuba, 27.06.2019
POHL, E., et al. Ageing in men with normal spermatogenesis alters spermatogonial dynamics and nuclear morphology in Sertoli cells. Andrology, 2019, 7. Jg., Nr. 6, S. 827-839.
Publication: https://doi.org/10.1111/andr.12665
Disclaimer
The publication Ageing in men with normal spermatogenesis alters spermatogonial dynamics and nuclear morphology in Sertoli cells by E. Pohl, V. Höffken, S. Schlatt, S. Kliesch, J. Gromoll, J. Wistuba is not published under an open access license.
Therefore, only content curated by the MFGA team can be shown.
For abstract, images and tables please follow the link to the original publication.
Curation by the MFGA team
Relevant data sets presented in the publication have been identified. If possible, annotations (title, general information,
conditions, processed tissue types and processed cell types) have been added based on information from the publication.
Data set 1: Spermatogenic dynamics in different age groups from men with normal spermatogenesis
Proteome: Immunohistochemistry
Conditions
| Human phenotype ontology |
Participants |
Comment |
| HP:0000027: Azoospermia |
|
Obstructive azoospermia; non-obstructive azoospermia |
| HP:other: Other |
28.0 |
3 Participant groups: groups: (1) 28.8 ± 2.7 years; (2) 48.1 ± 1 years; and (3) 70.9 ± 6.2 years, n = 8. Specific conditions can be examined in Table 1. |
Tissue Types
| BRENDA tissue ontology |
Maturity |
Description |
Species |
Replicates |
| BTO_0001363: testis |
|
Patients in groups 1 and 2 presented with obstructive azoospermia. Samples of subjects of age group 3 were obtained from elderly patients who underwent orchiectomy because of prostate cancer. |
Human |
|
Cell Types
| Cell ontology |
Maturity |
Description |
Species |
Replicates |
Cells per replicate |
| CL_0000019: sperm |
|
|
|
|
|
| CL_0000020: spermatogonium |
|
|
|
|
|
Data set 2: Proliferation of spermatogonia and spermatogenic efficiency
Proteome: Immunohistochemistry
Conditions
| Human phenotype ontology |
Participants |
Comment |
| HP:other: Other |
28 |
3 Participant groups: groups: (1) 28.8 ± 2.7 years; (2) 48.1 ± 1 years; and (3) 70.9 ± 6.2 years, n = 8. Specific conditions can be examined in Table 1. |
Data set 3: Nuclear and nucleolar morphometry in Sertoli cells
Other: Immunohistochemistry
Conditions
| Human phenotype ontology |
Participants |
Comment |
| HP:other: Other |
28 |
3 Participant groups: groups: (1) 28.8 ± 2.7 years; (2) 48.1 ± 1 years; and (3) 70.9 ± 6.2 years, n = 8. Specific conditions can be examined in Table 1. |
Data set 4: Comparative analysis to patients with meiotic arrest
Proteome: Immunohistochemistry
Conditions
| Human phenotype ontology |
Participants |
Comment |
| HP:0000027: Azoospermia |
8 |
Participant group with meiotic arrest, patients (29.9 ± 3.8 years, n = 8). |
| HP:other: Other |
28 |
3 Participant groups: groups: (1) 28.8 ± 2.7 years; (2) 48.1 ± 1 years; and (3) 70.9 ± 6.2 years, n = 8. Specific conditions can be examined in Table 1. |
