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Whole-exome sequencing of a large Chinese azoospermia and severe oligospermia cohort identifies novel infertility causative variants and genes

Shitao Chen, Guishuan Wang, Xiaoguo Zheng, Shunna Ge, Yubing Dai, Ping Ping, Xiangfeng Chen, Guihua Liu, Jing Zhang, Yang Yang, Xinzong Zhang, An Zhong, Yongtong Zhu, Qingjun Chu, Yonghan Huang, Yong Zhang, Changli Shen, Yiming Yuan, Qilong Yuan, Xiuying Pei, C Yan Cheng, Fei Sun, 15.07.2020

Shitao Chen et al. Whole-exome sequencing of a large Chinese azoospermia and severe oligospermia cohort identifies novel infertility causative variants and genes, Human Molecular Genetics, Volume 29, Issue 14, Pages 2451–2459, 15. July 2020

Publication: https://doi.org/10.1093/hmg/ddaa101

Disclaimer

The publication Whole-exome sequencing of a large Chinese azoospermia and severe oligospermia cohort identifies novel infertility causative variants and genes by Shitao Chen, Guishuan Wang, Xiaoguo Zheng, Shunna Ge, Yubing Dai, Ping Ping, Xiangfeng Chen, Guihua Liu, Jing Zhang, Yang Yang, Xinzong Zhang, An Zhong, Yongtong Zhu, Qingjun Chu, Yonghan Huang, Yong Zhang, Changli Shen, Yiming Yuan, Qilong Yuan, Xiuying Pei, C Yan Cheng, Fei Sun is not published under an open access license. Therefore, only content curated by the MFGA team can be shown. For abstract, images and tables please follow the link to the original publication.

Curation by the MFGA team
Relevant data sets presented in the publication have been identified. If possible, annotations (title, general information, conditions, processed tissue types and processed cell types) have been added based on information from the publication.

Data set 1: Analysis of the NOA/SO Exomes

Exome: Genome-wide Association Study

Species

Species
Human

Conditions

Human phenotype ontology Participants Comment
HP:0011961: Non-obstructive azoospermia 291 Patients of Chinese Han origin with non-obstructive azoospermia (NOA.)
HP:0000798: Oligozoospermia 23 Patients of Chinese Han origin with severe oligospermia (SO.)
HP:control 400 Fertile men

Data set 2: Evaluation of the WES data of unsolved cases to identify potentially novel genetic causes of human NOA

Exome: Genome-wide Association Study

Species

Species
Human

Conditions

Human phenotype ontology Participants Comment
HP:0011961: Non-obstructive azoospermia 302 302 unsolved cases to identify potentially novel genetic causes of human NOA