Male Fertility Gene Atlas

CRU Male Germ Cells

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Table 1. Effect on the suscepitibility to Sertoli cell-only (SCO) phenotype of the residues at position 13 of the HLA-DRß1 molecule

Cerván-Martín M, Tüttelmann F, Lopes AM, Bossini-Castillo L, Rivera-Egea R, Garrido N, Lujan S, Romeu G, Santos-Ribeiro S, Castilla JA, Carmen Gonzalvo M, Clavero A, Maldonado V, Vicente FJ, González-Muñoz S, Guzmán-Jiménez A, Burgos M, Jiménez R, Pacheco A, González C, Gómez S, Amorós D, Aguilar J, Quintana F, Calhaz-Jorge C, Aguiar A, Nunes J, Sousa S, Pereira I, Pinto MG, Correia S, Sánchez-Curbelo J, López-Rodrigo O, Martín J, Pereira-Caetano I, Marques PI, Carvalho F, Barros A, Gromoll J, Bassas L, Seixas S, Gonçalves J, Larriba S, Kliesch S, Palomino-Morales RJ, Carmona FD. Immune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility. Commun Biol. 2022 Nov 10;5(1):1220. doi: 10.1038/s42003-022-04192-0. PMID: 36357561; PMCID: PMC9649734.

Publication: https://www.nature.com/articles/s42003-022-04192-0

Description

The results of the combined analysis by logistic regression and the classical MHC alleles in our dataset that contain those amino acids are shown. OR odds ratio for the reference residue, CI confidence interval.

Disclaimer

The publication Immune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility by Cerván-Martín M, Tüttelmann F, Lopes AM, Bossini-Castillo L, Rivera-Egea R, Garrido N, Lujan S, Romeu G, Santos-Ribeiro S, Castilla JA, Carmen Gonzalvo M, Clavero A, Maldonado V, Vicente FJ, González-Muñoz S, Guzmán-Jiménez A, Burgos M, Jiménez R, Pacheco A, González C, Gómez S, Amorós D, Aguilar J, Quintana F, Calhaz-Jorge C, Aguiar A, Nunes J, Sousa S, Pereira I, Pinto MG, Correia S, Sánchez-Curbelo J, López-Rodrigo O, Martín J, Pereira-Caetano I, Marques PI, Carvalho F, Barros A, Gromoll J, Bassas L, Seixas S, Gonçalves J, Larriba S, Kliesch S, Palomino-Morales RJ, Carmona FD. is published under an open access license: https://creativecommons.org/licenses/by/4.0/. Permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Curation by the MFGA team

Pie chart of selected column

Table

ARTIFACTID SCO Frequency Control Frequency P OR
Ser 51.40 37.75 1.32E-08 1.80
Arg 8.65 14.07 7.93E-04 0.55
Tyr 11.45 15.43 3.86E-02 0.72
Gly 3.51 5.36 9.71E-02 0.63
Phe 11.21 13.40 1.96E-01 0.81
His 13.79 13.99 7.26E-01 0.95