Male Fertility Gene Atlas

CRU Male Germ Cells

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Table S1: List of Gene Markers Used to Identify Somatic and Germ Cell Clusters

SOHNI, Abhishek, et al. The Neonatal and Adult Human Testis Defined at the Single-Cell Level. Cell reports, 2019, 26. Jg., Nr. 6, S. 1501-1517. e4.

Publication: https://doi.org/10.1016/j.celrep.2019.01.045

Description

Related to Figures 1, 5, S1, and S5.
*NANOS3, PGC expression and turned off in SSC, but on again in Progenitors and diff SPG.
*MAGEA4 - PreSG specific marker. Off or low at PGC but on at ProSG. But lower again in SSC. Increased in Progenitors and diff SPG.
*DDX4 - General germ cell marker, expressed broad range of germ cells from PreSG to St. But low in PGCs.
*KIT - expressed in PGC but low until Diff SPG.
#UTF1 - expressed in PGC as well.
Changes in the table conducted for representation in the MFGA:
Table format has been adjusted.
Marker Genes were separated into single rows according to cell type.

Disclaimer

The publication The Neonatal and Adult Human Testis Defined at the Single-Cell Level by Abhishek Sohni, Kun Tan, Hye-Won Song, Dana Burow, Dirk G.de Rooij, Louise Laurent, Tung-Chin Hsieh, Raja Rabah, Saher Sue Hammoud, Elena Vicini, Miles F. Wilkinson is published under an open access no derivatives license: : https://creativecommons.org/licenses/by-nc-nd/4.0/. Granted rights: share — copy and redistribute the material in any medium or format. No alterations allowed. Thus, tables can not be shown in MFGA format.

Curation by the MFGA team

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Table

GENE CellType Cell
GATA1 SomaticCells Sertoli(adult)
WT1 SomaticCells Sertoli(adult)
GATA4 SomaticCells Sertoli(adult)
INHA SomaticCells Sertoli(prepubertal)
SOX9 SomaticCells Sertoli(prepubertal)
SOX4 SomaticCells Sertoli(prepubertal)
INHBB SomaticCells Sertoli(prepubertal)
MYH11 SomaticCells PTM(Adult)
CNN1 SomaticCells PTM(Adult)
SMA SomaticCells PTM(Adult)
ACTA2 SomaticCells PTM(Adult)
TPM1 SomaticCells PTM (Adult)
TAGLN Somatic Cells PTM(Fetal)
HSD3B2 SomaticCells LC(Adult)
IGF1 SomaticCells LC(Adult)
INSL3 SomaticCells LC(Adult)
STAR SomaticCells LC(Adult)
SF1 SomaticCells LC(Adult)
CYP1B1 SomaticCells LC(Adult)
HSD3B1 SomaticCells LC(Adult)
INHBA SomaticCells LC(prepubertal)
VCAM1 SomaticCells LC(fetal)
TSP2 SomaticCells LC(fetal)
CD34 SomaticCells Endothelial
CD74 SomaticCells Blood
HLA-DRB1 SomaticCells Blood
HBA2 SomaticCells Blood
HBG2 SomaticCells Blood
HBG1 SomaticCells Blood
AIF1 SomaticCells Macrophage
CD68 SomaticCells Macrophage
MGP SomaticCells Stroma
GNG11 SomaticCells Stroma
SPARCL1 SomaticCells Stroma
SLC9A3R2 SomaticCells Stroma
HLA-B SomaticCells Stroma
KLF2 SomaticCells Stroma
FSP1 SomaticCells Fibroblasts
POU5F1 GermCells PGC
NANOG GermCells PGC
SOX17 GermCells PGC
TFAPC2 GermCells PGC
NANOS3 GermCells PGC
PDPN GermCells PGC
KIT GermCells PGC
TCL1A GermCells PGC
ZFP42 GermCells PGC
SOX15 GermCells PGC
DPPA3 GermCells PGC
TET1 GermCells PGC
T GermCells PGC
CD38 GermCells PGC
PRDM1 GermCells PGC
PIWIL1 GermCells PGC
DND1 GermCells PGC
PIWIL4 GermCells PreSG
DDX4 GermCells PreSG
MAGEA4 GermCells PreSG
PIWIL2 GermCells PreSG
UTF1 GermCells PreSG
TEX14 GermCells PreSG
TEX15 GermCells PreSG
TDRD6 GermCells PreSG
KLF5 GermCells PreSG
TFCP2L GermCells PreSG
CPEB1 GermCells PreSG
LIN7B GermCells SSC
C19orf84 GermCells SSC
PIWIL4 GermCells SSC
UTF1 GermCells SSC
MAGEB2 GermCells SSC
PODXL2 GermCells SSC
EGR4 GermCells SSC
FSD1 GermCells SSC
RAC3 GermCells SSC
TCF3 GermCells SSC
MSL3 GermCells SSC
MORC1 GermCells SSC
STK31 GermCells SSC
NOC4L GermCells SSC
LPPR5 Germ Cells SSC
SURF2 GermCells SSC
RGS14 GermCells SSC
PTRHD1 GermCells SSC
ENHO GermCells SSC
SH2B2 GermCells SSC
CPEB1 GermCells SSC
NGN3 GermCells Progenitors
NANOS3 GermCells Progenitors
MAGEA4 GermCells Progenitors
ID4 GermCells UndiffSPG
ZBTB16 GermCells UndiffSPG
BCL6B GermCells UndiffSPG
LIN28 GermCells UndiffSPG
UTF1 GermCells UndiffSPG
SALL4 GermCells UndiffSPG
FGFR3 GermCells UndiffSPG
KIT GermCells DiffSPG
SOHLH1 GermCells DiffSPG
SOHLH2 GermCells DiffSPG
STRA8 GermCells DiffSPG
DMRT1 GermCells DiffSPG
REC8 GermCells SPC
SPO11 GermCells SPC
RAD51 GermCells SPC
ACRROSIN GermCells SPC
SYCP1 GermCells SPC
SYCP3 GermCells SPC
STRA8 GermCells SPC
TNP1 GermCells St
TNP2 GermCells St
PRM1 GermCells St
PRM2 GermCells St