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Table S3: Architecture of the LßT2

RUF-ZAMOJSKI, Frederique, et al. Regulatory architecture of the LβT2 gonadotrope cell underlying the response to gonadotropin-releasing hormone. Frontiers in endocrinology, 2018, 9. Jg., S. 34.

Publication: https://www.frontiersin.org/articles/10.3389/fendo.2018.00034/full

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The publication Regulatory Architecture of the LβT2 Gonadotrope Cell Underlying the Response to Gonadotropin-Releasing Hormone by Frederique Ruf-Zamojski, Miguel Fribourg, Yongchao Ge, Venugopalan Nair, Hanna Pincas, Elena Zaslavsky, German Nudelman, Stephanie J. Tuminello, Hideo Watanabe, Judith L. Turgeon and Stuart C. Sealfon is published under an open access license: https://creativecommons.org/licenses/by/4.0/. Granted rights: share — copy and redistribute the material in any medium or format and adapt — remix, transform, and build upon the material for any purpose, even commercially.

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Table

GENE Pathways.processes.diseases Database.my.gene.sets.gene.ontology.kegg Freq...network.vs..genome. P.value..fdr.corrected.
CDKN1C GO-BP-0071363:cellular response to growth factor stimulus Gene Ontology 20.0% (7/35) 1.8% (168/9324) 0.000878
EGR3 GO-BP-0071363:cellular response to growth factor stimulus Gene Ontology 20.0% (7/35) 1.8% (168/9324) 0.000878
FGFR3 GO-BP-0071363:cellular response to growth factor stimulus Gene Ontology 20.0% (7/35) 1.8% (168/9324) 0.000878
FOS GO-BP-0071363:cellular response to growth factor stimulus Gene Ontology 20.0% (7/35) 1.8% (168/9324) 0.000878
NR4A1 GO-BP-0071363:cellular response to growth factor stimulus Gene Ontology 20.0% (7/35) 1.8% (168/9324) 0.000878
JUN GO-BP-0071363:cellular response to growth factor stimulus Gene Ontology 20.0% (7/35) 1.8% (168/9324) 0.000878
SFRP1 GO-BP-0071363:cellular response to growth factor stimulus Gene Ontology 20.0% (7/35) 1.8% (168/9324) 0.000878
CDKN1C GO-BP-0070848:response to growth factor Gene Ontology 20.0% (7/35) 1.9% (177/9324) 0.000829
EGR3 GO-BP-0070848:response to growth factor Gene Ontology 20.0% (7/35) 1.9% (177/9324) 0.000829
FGFR3 GO-BP-0070848:response to growth factor Gene Ontology 20.0% (7/35) 1.9% (177/9324) 0.000829
FOS GO-BP-0070848:response to growth factor Gene Ontology 20.0% (7/35) 1.9% (177/9324) 0.000829
NR4A1 GO-BP-0070848:response to growth factor Gene Ontology 20.0% (7/35) 1.9% (177/9324) 0.000829
JUN GO-BP-0070848:response to growth factor Gene Ontology 20.0% (7/35) 1.9% (177/9324) 0.000829
SFRP1 GO-BP-0070848:response to growth factor Gene Ontology 20.0% (7/35) 1.9% (177/9324) 0.000829
EGR3 GO-BP-0044344:cellular response to fibroblast growth factor stimulus Gene Ontology 11.4% (4/35) 0.4% (37/9324) 0.00185
FGFR3 GO-BP-0044344:cellular response to fibroblast growth factor stimulus Gene Ontology 11.4% (4/35) 0.4% (37/9324) 0.00185
NR4A1 GO-BP-0044344:cellular response to fibroblast growth factor stimulus Gene Ontology 11.4% (4/35) 0.4% (37/9324) 0.00185
SFRP1 GO-BP-0044344:cellular response to fibroblast growth factor stimulus Gene Ontology 11.4% (4/35) 0.4% (37/9324) 0.00185
EGR3 GO-BP-0071774:response to fibroblast growth factor Gene Ontology 11.4% (4/35) 0.4% (37/9324) 0.00148
FGFR3 GO-BP-0071774:response to fibroblast growth factor Gene Ontology 11.4% (4/35) 0.4% (37/9324) 0.00148
NR4A1 GO-BP-0071774:response to fibroblast growth factor Gene Ontology 11.4% (4/35) 0.4% (37/9324) 0.00148
SFRP1 GO-BP-0071774:response to fibroblast growth factor Gene Ontology 11.4% (4/35) 0.4% (37/9324) 0.00148
ATF3 KEGG-Pathway-hsa05166: HTLV-I infection - Homo sapiens (human) KEGG 20.0% (7/35) 2.8% (263/9324) 0.00548
CREBBP KEGG-Pathway-hsa05166: HTLV-I infection - Homo sapiens (human) KEGG 20.0% (7/35) 2.8% (263/9324) 0.00548
EGR1 KEGG-Pathway-hsa05166: HTLV-I infection - Homo sapiens (human) KEGG 20.0% (7/35) 2.8% (263/9324) 0.00548
EGR2 KEGG-Pathway-hsa05166: HTLV-I infection - Homo sapiens (human) KEGG 20.0% (7/35) 2.8% (263/9324) 0.00548
FOS KEGG-Pathway-hsa05166: HTLV-I infection - Homo sapiens (human) KEGG 20.0% (7/35) 2.8% (263/9324) 0.00548
JUN KEGG-Pathway-hsa05166: HTLV-I infection - Homo sapiens (human) KEGG 20.0% (7/35) 2.8% (263/9324) 0.00548
ZFP36 KEGG-Pathway-hsa05166: HTLV-I infection - Homo sapiens (human) KEGG 20.0% (7/35) 2.8% (263/9324) 0.00548
EFNB2 GO-BP-0002042:cell migration involved in sprouting angiogenesis Gene Ontology 8.6% (3/35) 0.2% (19/9324) 0.00473
EGR3 GO-BP-0002042:cell migration involved in sprouting angiogenesis Gene Ontology 8.6% (3/35) 0.2% (19/9324) 0.00473
NR4A1 GO-BP-0002042:cell migration involved in sprouting angiogenesis Gene Ontology 8.6% (3/35) 0.2% (19/9324) 0.00473
CDKN1C GO-BP-0071495:cellular response to endogenous stimulus Gene Ontology 20.0% (7/35) 3.0% (278/9324) 0.00585
EGR3 GO-BP-0071495:cellular response to endogenous stimulus Gene Ontology 20.0% (7/35) 3.0% (278/9324) 0.00585
FGFR3 GO-BP-0071495:cellular response to endogenous stimulus Gene Ontology 20.0% (7/35) 3.0% (278/9324) 0.00585
FOS GO-BP-0071495:cellular response to endogenous stimulus Gene Ontology 20.0% (7/35) 3.0% (278/9324) 0.00585
NR4A1 GO-BP-0071495:cellular response to endogenous stimulus Gene Ontology 20.0% (7/35) 3.0% (278/9324) 0.00585
JUN GO-BP-0071495:cellular response to endogenous stimulus Gene Ontology 20.0% (7/35) 3.0% (278/9324) 0.00585
SFRP1 GO-BP-0071495:cellular response to endogenous stimulus Gene Ontology 20.0% (7/35) 3.0% (278/9324) 0.00585
FOS KEGG-Pathway-hsa04380: Osteoclast differentiation - Homo sapiens (human) KEGG 14.3% (5/35) 1.4% (132/9324) 0.00992
FOSB KEGG-Pathway-hsa04380: Osteoclast differentiation - Homo sapiens (human) KEGG 14.3% (5/35) 1.4% (132/9324) 0.00992
FOSL2 KEGG-Pathway-hsa04380: Osteoclast differentiation - Homo sapiens (human) KEGG 14.3% (5/35) 1.4% (132/9324) 0.00992
JUN KEGG-Pathway-hsa04380: Osteoclast differentiation - Homo sapiens (human) KEGG 14.3% (5/35) 1.4% (132/9324) 0.00992
JUNB KEGG-Pathway-hsa04380: Osteoclast differentiation - Homo sapiens (human) KEGG 14.3% (5/35) 1.4% (132/9324) 0.00992
EFNB2 GO-BP-0002040:sprouting angiogenesis Gene Ontology 8.6% (3/35) 0.3% (28/9324) 0.0109
EGR3 GO-BP-0002040:sprouting angiogenesis Gene Ontology 8.6% (3/35) 0.3% (28/9324) 0.0109
NR4A1 GO-BP-0002040:sprouting angiogenesis Gene Ontology 8.6% (3/35) 0.3% (28/9324) 0.0109
CREBBP GO-BP-0000122:negative regulation of transcription from RNA polymerase II promoter Gene Ontology 17.1% (6/35) 2.4% (225/9324) 0.0111
NFIL3 GO-BP-0000122:negative regulation of transcription from RNA polymerase II promoter Gene Ontology 17.1% (6/35) 2.4% (225/9324) 0.0111
PITX2 GO-BP-0000122:negative regulation of transcription from RNA polymerase II promoter Gene Ontology 17.1% (6/35) 2.4% (225/9324) 0.0111
ZFP36 GO-BP-0000122:negative regulation of transcription from RNA polymerase II promoter Gene Ontology 17.1% (6/35) 2.4% (225/9324) 0.0111
BHLHE40 GO-BP-0000122:negative regulation of transcription from RNA polymerase II promoter Gene Ontology 17.1% (6/35) 2.4% (225/9324) 0.0111
CITED2 GO-BP-0000122:negative regulation of transcription from RNA polymerase II promoter Gene Ontology 17.1% (6/35) 2.4% (225/9324) 0.0111
CREBBP KEGG-Pathway-hsa05161: Hepatitis B - Homo sapiens (human) KEGG 14.3% (5/35) 1.6% (146/9324) 0.012
EGR2 KEGG-Pathway-hsa05161: Hepatitis B - Homo sapiens (human) KEGG 14.3% (5/35) 1.6% (146/9324) 0.012
EGR3 KEGG-Pathway-hsa05161: Hepatitis B - Homo sapiens (human) KEGG 14.3% (5/35) 1.6% (146/9324) 0.012
FOS KEGG-Pathway-hsa05161: Hepatitis B - Homo sapiens (human) KEGG 14.3% (5/35) 1.6% (146/9324) 0.012
JUN KEGG-Pathway-hsa05161: Hepatitis B - Homo sapiens (human) KEGG 14.3% (5/35) 1.6% (146/9324) 0.012
CDKN1C GO-BP-0071559:response to transforming growth factor beta Gene Ontology 11.4% (4/35) 0.8% (79/9324) 0.0116
FOS GO-BP-0071559:response to transforming growth factor beta Gene Ontology 11.4% (4/35) 0.8% (79/9324) 0.0116
JUN GO-BP-0071559:response to transforming growth factor beta Gene Ontology 11.4% (4/35) 0.8% (79/9324) 0.0116
SFRP1 GO-BP-0071559:response to transforming growth factor beta Gene Ontology 11.4% (4/35) 0.8% (79/9324) 0.0116
CDKN1C GO-BP-0071560:cellular response to transforming growth factor beta stimulus Gene Ontology 11.4% (4/35) 0.8% (79/9324) 0.0107
FOS GO-BP-0071560:cellular response to transforming growth factor beta stimulus Gene Ontology 11.4% (4/35) 0.8% (79/9324) 0.0107
JUN GO-BP-0071560:cellular response to transforming growth factor beta stimulus Gene Ontology 11.4% (4/35) 0.8% (79/9324) 0.0107
SFRP1 GO-BP-0071560:cellular response to transforming growth factor beta stimulus Gene Ontology 11.4% (4/35) 0.8% (79/9324) 0.0107
DUSP1 KEGG-Pathway-hsa04010: MAPK signaling pathway - Homo sapiens (human) KEGG 17.1% (6/35) 2.8% (259/9324) 0.0175
DUSP5 KEGG-Pathway-hsa04010: MAPK signaling pathway - Homo sapiens (human) KEGG 17.1% (6/35) 2.8% (259/9324) 0.0175
FGFR3 KEGG-Pathway-hsa04010: MAPK signaling pathway - Homo sapiens (human) KEGG 17.1% (6/35) 2.8% (259/9324) 0.0175
FOS KEGG-Pathway-hsa04010: MAPK signaling pathway - Homo sapiens (human) KEGG 17.1% (6/35) 2.8% (259/9324) 0.0175
NR4A1 KEGG-Pathway-hsa04010: MAPK signaling pathway - Homo sapiens (human) KEGG 17.1% (6/35) 2.8% (259/9324) 0.0175
JUN KEGG-Pathway-hsa04010: MAPK signaling pathway - Homo sapiens (human) KEGG 17.1% (6/35) 2.8% (259/9324) 0.0175
ZFP36 GO-BP-0000289:nuclear-transcribed mRNA poly(A) tail shortening Gene Ontology 5.7% (2/35) 0.1% (8/9324) 0.0173
BTG2 GO-BP-0000289:nuclear-transcribed mRNA poly(A) tail shortening Gene Ontology 5.7% (2/35) 0.1% (8/9324) 0.0173
ZFP36 GO-BP-0060211:regulation of nuclear-transcribed mRNA poly(A) tail shortening Gene Ontology 5.7% (2/35) 0.1% (8/9324) 0.0163
BTG2 GO-BP-0060211:regulation of nuclear-transcribed mRNA poly(A) tail shortening Gene Ontology 5.7% (2/35) 0.1% (8/9324) 0.0163
ZFP36 GO-BP-1900151:regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Gene Ontology 5.7% (2/35) 0.1% (8/9324) 0.0154
BTG2 GO-BP-1900151:regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Gene Ontology 5.7% (2/35) 0.1% (8/9324) 0.0154
ZFP36 GO-BP-0060213:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Gene Ontology 5.7% (2/35) 0.1% (8/9324) 0.0146
BTG2 GO-BP-0060213:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Gene Ontology 5.7% (2/35) 0.1% (8/9324) 0.0146
EFNB2 GO-BP-0043534:blood vessel endothelial cell migration Gene Ontology 8.6% (3/35) 0.4% (40/9324) 0.016
EGR3 GO-BP-0043534:blood vessel endothelial cell migration Gene Ontology 8.6% (3/35) 0.4% (40/9324) 0.016
NR4A1 GO-BP-0043534:blood vessel endothelial cell migration Gene Ontology 8.6% (3/35) 0.4% (40/9324) 0.016
EGR3 GO-BP-0035767:endothelial cell chemotaxis Gene Ontology 5.7% (2/35) 0.1% (10/9324) 0.0211
NR4A1 GO-BP-0035767:endothelial cell chemotaxis Gene Ontology 5.7% (2/35) 0.1% (10/9324) 0.0211
ZFP36 GO-BP-0061014:positive regulation of mRNA catabolic process Gene Ontology 5.7% (2/35) 0.1% (10/9324) 0.0202
BTG2 GO-BP-0061014:positive regulation of mRNA catabolic process Gene Ontology 5.7% (2/35) 0.1% (10/9324) 0.0202
FOS GO-BP-0060395:SMAD protein signal transduction Gene Ontology 5.7% (2/35) 0.1% (10/9324) 0.0193
JUN GO-BP-0060395:SMAD protein signal transduction Gene Ontology 5.7% (2/35) 0.1% (10/9324) 0.0193
CDKN1C GO-BP-0050678:regulation of epithelial cell proliferation Gene Ontology 11.4% (4/35) 1.1% (106/9324) 0.0193
EGR3 GO-BP-0050678:regulation of epithelial cell proliferation Gene Ontology 11.4% (4/35) 1.1% (106/9324) 0.0193
NR4A1 GO-BP-0050678:regulation of epithelial cell proliferation Gene Ontology 11.4% (4/35) 1.1% (106/9324) 0.0193
SFRP1 GO-BP-0050678:regulation of epithelial cell proliferation Gene Ontology 11.4% (4/35) 1.1% (106/9324) 0.0193
CEBPB KEGG-Pathway-hsa04668: TNF signaling pathway - Homo sapiens (human) KEGG 11.4% (4/35) 1.2% (110/9324) 0.0213
FOS KEGG-Pathway-hsa04668: TNF signaling pathway - Homo sapiens (human) KEGG 11.4% (4/35) 1.2% (110/9324) 0.0213
JUN KEGG-Pathway-hsa04668: TNF signaling pathway - Homo sapiens (human) KEGG 11.4% (4/35) 1.2% (110/9324) 0.0213
JUNB KEGG-Pathway-hsa04668: TNF signaling pathway - Homo sapiens (human) KEGG 11.4% (4/35) 1.2% (110/9324) 0.0213
ZFP36 GO-BP-0061013:regulation of mRNA catabolic process Gene Ontology 5.7% (2/35) 0.1% (11/9324) 0.0208
BTG2 GO-BP-0061013:regulation of mRNA catabolic process Gene Ontology 5.7% (2/35) 0.1% (11/9324) 0.0208
ZFP36 GO-BP-0031442:positive regulation of mRNA 3-end processing Gene Ontology 5.7% (2/35) 0.1% (12/9324) 0.024
BTG2 GO-BP-0031442:positive regulation of mRNA 3-end processing Gene Ontology 5.7% (2/35) 0.1% (12/9324) 0.024
ZFP36 GO-BP-0031440:regulation of mRNA 3-end processing Gene Ontology 5.7% (2/35) 0.1% (12/9324) 0.0231
BTG2 GO-BP-0031440:regulation of mRNA 3-end processing Gene Ontology 5.7% (2/35) 0.1% (12/9324) 0.0231
CDKN1C GO-BP-0050673:epithelial cell proliferation Gene Ontology 11.4% (4/35) 1.3% (121/9324) 0.0262
EGR3 GO-BP-0050673:epithelial cell proliferation Gene Ontology 11.4% (4/35) 1.3% (121/9324) 0.0262
NR4A1 GO-BP-0050673:epithelial cell proliferation Gene Ontology 11.4% (4/35) 1.3% (121/9324) 0.0262
SFRP1 GO-BP-0050673:epithelial cell proliferation Gene Ontology 11.4% (4/35) 1.3% (121/9324) 0.0262
ZFP36 GO-BP-0000288:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Gene Ontology 5.7% (2/35) 0.2% (14/9324) 0.0296
BTG2 GO-BP-0000288:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Gene Ontology 5.7% (2/35) 0.2% (14/9324) 0.0296
CDKN1C GO-BP-0007179:transforming growth factor beta receptor signaling pathway Gene Ontology 8.6% (3/35) 0.7% (61/9324) 0.0356
FOS GO-BP-0007179:transforming growth factor beta receptor signaling pathway Gene Ontology 8.6% (3/35) 0.7% (61/9324) 0.0356
JUN GO-BP-0007179:transforming growth factor beta receptor signaling pathway Gene Ontology 8.6% (3/35) 0.7% (61/9324) 0.0356
EGR3 GO-BP-0050679:positive regulation of epithelial cell proliferation Gene Ontology 8.6% (3/35) 0.7% (62/9324) 0.0361
NR4A1 GO-BP-0050679:positive regulation of epithelial cell proliferation Gene Ontology 8.6% (3/35) 0.7% (62/9324) 0.0361
SFRP1 GO-BP-0050679:positive regulation of epithelial cell proliferation Gene Ontology 8.6% (3/35) 0.7% (62/9324) 0.0361
ZFP36 GO-BP-0050685:positive regulation of mRNA processing Gene Ontology 5.7% (2/35) 0.2% (17/9324) 0.04
BTG2 GO-BP-0050685:positive regulation of mRNA processing Gene Ontology 5.7% (2/35) 0.2% (17/9324) 0.04
FOS KEGG-Pathway-hsa05031: Amphetamine addiction - Homo sapiens (human) KEGG 8.6% (3/35) 0.7% (68/9324) 0.0444
FOSB KEGG-Pathway-hsa05031: Amphetamine addiction - Homo sapiens (human) KEGG 8.6% (3/35) 0.7% (68/9324) 0.0444
JUN KEGG-Pathway-hsa05031: Amphetamine addiction - Homo sapiens (human) KEGG 8.6% (3/35) 0.7% (68/9324) 0.0444
SFRP1 GO-BP-0048511:rhythmic process Gene Ontology 5.7% (2/35) 0.2% (19/9324) 0.0472
BHLHE40 GO-BP-0048511:rhythmic process Gene Ontology 5.7% (2/35) 0.2% (19/9324) 0.0472
EFNB2 GO-BP-0072359:circulatory system development Gene Ontology 14.3% (5/35) 2.7% (252/9324) 0.0472
EGR3 GO-BP-0072359:circulatory system development Gene Ontology 14.3% (5/35) 2.7% (252/9324) 0.0472
NR4A1 GO-BP-0072359:circulatory system development Gene Ontology 14.3% (5/35) 2.7% (252/9324) 0.0472
MYLK GO-BP-0072359:circulatory system development Gene Ontology 14.3% (5/35) 2.7% (252/9324) 0.0472
CITED2 GO-BP-0072359:circulatory system development Gene Ontology 14.3% (5/35) 2.7% (252/9324) 0.0472
EFNB2 GO-BP-0072358:cardiovascular system development Gene Ontology 14.3% (5/35) 2.7% (252/9324) 0.046
EGR3 GO-BP-0072358:cardiovascular system development Gene Ontology 14.3% (5/35) 2.7% (252/9324) 0.046
NR4A1 GO-BP-0072358:cardiovascular system development Gene Ontology 14.3% (5/35) 2.7% (252/9324) 0.046
MYLK GO-BP-0072358:cardiovascular system development Gene Ontology 14.3% (5/35) 2.7% (252/9324) 0.046
CITED2 GO-BP-0072358:cardiovascular system development Gene Ontology 14.3% (5/35) 2.7% (252/9324) 0.046
EFNB2 GO-BP-0048514:blood vessel morphogenesis Gene Ontology 11.4% (4/35) 1.6% (153/9324) 0.0475
EGR3 GO-BP-0048514:blood vessel morphogenesis Gene Ontology 11.4% (4/35) 1.6% (153/9324) 0.0475
NR4A1 GO-BP-0048514:blood vessel morphogenesis Gene Ontology 11.4% (4/35) 1.6% (153/9324) 0.0475
MYLK GO-BP-0048514:blood vessel morphogenesis Gene Ontology 11.4% (4/35) 1.6% (153/9324) 0.0475
NR4A2 GO-BP-0009991:response to extracellular stimulus Gene Ontology 8.6% (3/35) 0.8% (73/9324) 0.0474
SFRP1 GO-BP-0009991:response to extracellular stimulus Gene Ontology 8.6% (3/35) 0.8% (73/9324) 0.0474
ZFP36 GO-BP-0009991:response to extracellular stimulus Gene Ontology 8.6% (3/35) 0.8% (73/9324) 0.0474